ABT-737 is a potent, competitive BH3-mimetic inhibitor of Bcl-2, Bcl-xL, and Bcl-w. It affects intrinsic apoptotic signaling by displacing pro-apoptotic proteins like Bax and Bak, effectively promoting mitochondrial outer membrane permeabilization and cancer cell apoptosis.
ABT-737 Mechanism of Action: Bcl-2 Inhibition in Cancer Cell Research
ABT-737 MOA：Targeting Bcl-2/Apoptosis Pathway for Oncology