CAS No. 1188890-28-9

Batch: Purity:99.76
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ABT 702 dihydrochloride Chemical Structure
Chemical Structure
Check the ABT 702 dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-(3-bromophenyl)-7-(6-morpholin-4-yl-3-pyridinyl)pyrido[2,3-d]pyrimidin-4-amine;dihydrochloride
CAS Number 1188890-28-9
Molecular Formula

C22H21BrCl2N6O
Molecular Weight (MW) 536.25
SMILES C1COCCN1C2=NC=C(C=C2)C3=NC4=NC=NC(=C4C(=C3)C5=CC(=CC=C5)Br)N.Cl.Cl
InChIKey OOXNYFKPOPJIOT-UHFFFAOYSA-N

Ordering Information

Biological Activity

ABT-702 dihydrochloride is a potent non-nucleoside adenosine kinase inhibitor with an IC50 of. By inhibiting adenosine kinase activity, it blocks intracellular adenosine phosphorylation, elevating extracellular endogenous adenosine levels and enhancing purinergic signaling pathways. This mechanism attenuates nociceptive signal transmission and reduces pro-inflammatory mediator production, demonstrating pronounced antinociceptive and anti-inflammatory activity in preclinical animal models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (186.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.