CAS No. 1638200-22-2

Batch: Purity:99.61
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ABR-238901 Chemical Structure
Chemical Structure
Check the ABR-238901 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-bromo-N-(5-chloro-4-oxo-1H-pyridin-3-yl)-6-methoxypyridine-3-sulfonamide
CAS Number 1638200-22-2
Molecular Formula

C11H9BrClN3O4S
Molecular Weight (MW) 394.63
SMILES COC1=NC=C(C=C1Br)[S;v6](=O)(=O)NC2=CN=CC(=C2O)Cl
InChIKey IXVPHMAWVYMOQL-UHFFFAOYSA-N

Biological Activity

ABR-238901 is a small-molecule S100A8/A9 blocker that potently inhibits the interaction of S100A8/A9 with its receptors RAGE and TLR4. By disrupting S100A8/A9 receptor engagement, ABR-238901 suppresses downstream NF-kB signaling and reduces pro-inflammatory mediator expression. Consequently, pharmacological S100A/A9 blockade attenuates systemic inflammatory cytokine production, reduces neutrophil recruitment, and mitigates organ tissue damage and dysfunction in experimental models of severe sepsis. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 79 mg/mL (200.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Jakobsson G, et al. Crit Care. 2023;27(1):374.

[2] Ding Z, et al. Int J Mol Sci. 2021;22(23).

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Note: Technical data last updated: Sep 1, 2026.