CAS No. 149301-79-1
Batch:
Purity:100.00
Chemical Structure
Check the
AACOCF3
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one | |
|---|---|---|
| CAS Number | 149301-79-1 | |
| Molecular Formula |
C21H31F3O |
|
| Molecular Weight (MW) | 356.47 | |
| InChIKey | PLWROONZUDKYKG-DOFZRALJSA-N |
Biological Activity
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable analog of arachidonic acid that acts as an inhibitor of cytosolic phospholipase A2 (cPLA2) and calcium-independent phospholipase A2 (iPLA2). Pharmacological inhibition of cPLA2 blocks free arachidonic acid release and downstream eicosanoid biosynthesis. In a cholecalciferol-overload mouse model, treatment with AACOCF3 suppresses aortic osteoinductive signaling and significantly reduces vascular calcification. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(199.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 35 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.