CAS No. 457961-34-1
Batch:
Purity:99.43
Chemical Structure
Check the
AA92593
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 457961-34-1 | |
|---|---|---|
| Molecular Formula |
C13H19NO3S |
|
| Molecular Weight (MW) | 269.36 | |
| SMILES | COC1=C(C)C=C(C=C1)[S](=O)(=O)N2CCCCC2 |
AA92593 is a selective antagonist of melanopsin (OPN4) with an IC50 ofin a Ca2+ flux assay. By blocking OPN4-mediated signaling, it suppresses light-induced phototransduction in intrinsically photosensitive retinal ganglion cells (ipRGCs). Consequently, AA92593 inhibits downstream calcium influx and attenuates non-image-forming visual responses, providing a valuable tool for studying circadian photoentrainment and pupillary light reflexes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(200.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.