CAS No. 393121-74-9

Batch: Purity:99.39
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AA147 Chemical Structure
Chemical Structure
Check the AA147 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
CAS Number 393121-74-9
Molecular Formula

C16H17NO2
Molecular Weight (MW) 255.31
SMILES CC1=CC=C(O)C(=C1)NC(=O)CCC2=CC=CC=C2
InChIKey AWHLTHOHBAGPMY-UHFFFAOYSA-N

Ordering Information

Biological Activity

AA147 is a small-molecule endoplasmic reticulum (ER) proteostasis regulator that selectively activates the activating transcription factor 6 (ATF6) arm of the unfolded protein response (UPR). Following metabolic oxidation, AA147 covalently modifies ER-resident protein disulfide isomerases (PDIs) to induce ATF6 transcriptional activity. This activation reprograms cellular proteostasis, upregulates protective chaperones such as BiP, and mitigates cellular damage in ischemia/reperfusion injury models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 51 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 51 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.