CAS No. 570390-00-0
Batch:
Purity:99.76
Chemical Structure
Check the
A2ti-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide | |
|---|---|---|
| CAS Number | 570390-00-0 | |
| Molecular Formula |
C20H22N4O2S |
|
| Molecular Weight (MW) | 382.48 | |
| InChIKey | KNQGIFUBCFRGDB-UHFFFAOYSA-N |
Biological Activity
A2ti-1 is a selective, high-affinity inhibitor of the annexin A2/S100A10 heterotetramer (A2t) with an ICof. The compound specifically disrupts the protein-protein interaction between annexin A2 and S100A10, preventing heterotetramer complex assembly. This disruption impairs A2t-dependent non-canonical endocytic viral entry and intracellular trafficking, ultimately preventing human papillomavirus type 16 (HPV16) pseudovirion infection in epithelial host cells. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(201.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.