CAS No. 909910-43-6
Batch:
Purity:97
Chemical Structure
Check the
A-83-01
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(6-methyl-2-pyridinyl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide | |
|---|---|---|
| CAS Number | 909910-43-6 | |
| Molecular Formula |
C25H19N5S |
|
| Molecular Weight (MW) | 421.52 | |
| SMILES | CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5 | |
| InChIKey | HIJMSZGHKQPPJS-UHFFFAOYSA-N |
A-83-01 is a potent inhibitor of TGF-β type I receptors, targeting ALK5, ALK4, and ALK7. By blocking kinase activity, it suppresses TGF-β-induced Smad phosphorylation and prevents epithelial-to-mesenchymal transition (EMT) without affecting p38 MAPK or ERK pathways, thereby modulating cell differentiation and migration. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
21 mg/mL
(49.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
21 mg/mL
(49.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
21 mg/mL
(49.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
21 mg/mL
(49.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | ˂1 mg/mL |
| Ethanol | ˂1 mg/mL |
| DMSO |
23 mg/mL
(54.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | ˂1 mg/mL |
| Ethanol | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- A-83-01 Mechanism of Action: ALK5 Inhibition in Stem Cell Research
- A-83-01: Selectivity & Specificity
- A-83-01 Working Concentration | Cell Culture | Treatment
- A-83-01 Solubility in DMSO
- A-83-01 Stock Solution
- A-83-01 Storage
- A-83-01 Stability
- A-83-01 Combination Database
- A-83-01 Molecular Weight
- A-83-01 SMILES
- A-83-01 Chemical Structure (2D and 3D)
- A-83-01 MedChemExpress (HY-10432)? Try a better option.
- A-83-01 STEMCELL (72024)? Try a better option.
- A-83-01 Sigma (SML0788)? Try a better option.
- A-83-01 Tocris (2939)? Try a better option.
- A-83-01 Cell Signaling Technology (75073)? Try a better option.
- A-83-01 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.