CAS No. 944261-79-4
| IUPAC Name | 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide | |
|---|---|---|
| CAS Number | 944261-79-4 | |
| Molecular Formula |
C19H16ClNO4 |
|
| Molecular Weight (MW) | 357.79 | |
| SMILES | COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC | |
| InChIKey | VHKBTPQDHDSBSP-UHFFFAOYSA-N |
A-803467 is a selective NaV1.8 sodium channel blocker with an IC50 of 8 nM for human NaV1.8. It exhibits over 100-fold selectivity against other human sodium channel subtypes, including NaV1.2, NaV1.3, NaV1.5, and NaV1.7. By blocking tetrodotoxin-resistant currents and inhibiting action potential generation in sensory neurons, A-803467 suppresses pain transmission, demonstrating antinociceptive efficacy in animal models of inflammatory and neuropathic pain. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(201.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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