CAS No. 159432-28-7
Batch:
Purity:99.87
Chemical Structure
Check the
A-779
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 159432-28-7 | |
|---|---|---|
| Molecular Formula |
C39H60N12O11 |
|
| Molecular Weight (MW) | 872.97 | |
| SMILES | CCC(C)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(CC2=CN=C[NH]2)C(=O)NC(C)C(O)=O |
Biological Activity
A-is a selective peptide antagonist of the G protein-coupled receptor Mas (IC= that exhibits negligible affinity for AT1 and AT2 receptors. By blocking Mas receptor activation, A-779 reverses Ang-(1-7)-mediated suppression of reactive oxygen species and downstream AKT and ERK signaling pathways. Consequently, this antagonism counteracts Ang-(1-7) regulatory effects on cell proliferation, migration, and inflammatory responses. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(114.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 25 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.