CAS No. 861393-28-4
Batch:
Purity:99.00
Chemical Structure
Check the
A-740003
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[1-[[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide | |
|---|---|---|
| CAS Number | 861393-28-4 | |
| Molecular Formula |
C26H30N6O3 |
|
| Molecular Weight (MW) | 474.55 | |
| SMILES | CC(C)(C)C(NC(=O)CC1=CC(=C(C=C1)OC)OC)N=C(NC#N)NC2=CC=CC3=C2C=CC=N3 | |
| InChIKey | PUHSRMSFDASMAE-UHFFFAOYSA-N |
A-740003 is a potent and competitive P2X7 receptor antagonist that selectively inhibits rat P2X7 (IC50 = 18 nM) and human P2X7 (IC50 = 40 nM). Blockade of P2X7 activation by A-740003 effectively inhibits agonist-evoked pore formation (IC50 = 92 nM) and attenuates interleukin-1β release (IC50 = 156 nM) in differentiated human THP-1 cells, thereby suppressing inflammatory downstream signaling cascades and cellular phenotypes. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(200.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(200.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1.5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.