A-485 is a potent, highly selective CBP/p300 histone acetyltransferase inhibitor. It affects Notch, SENP1-Sirt3, and inflammatory signaling pathways. By reducing H3K27 and H3K18 acetylation to suppress target gene expression, it inhibits tumor proliferation, invasion, and inflammation, and promotes osteoblast differentiation.
A-485 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for A-485 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.