CAS No. 78957-85-4
Batch:
Purity:99.73
Chemical Structure
Check the
A-3 hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 78957-85-4 | |
|---|---|---|
| Molecular Formula |
C12H13ClN2O2S.ClH |
|
| Molecular Weight (MW) | 321.22 | |
| SMILES | Cl.NCCN[S](=O)(=O)C1=C2C=CC=C(Cl)C2=CC=C1 |
A-3 hydrochloride is a cell-permeable, ATP-competitive kinase inhibitor that acts as a broad-spectrum antagonist targeting PKA, CK2, MLCK (Ki 7.4 µM), PKC, and CK1. By directly inhibiting these serine/threonine kinases, A-3 suppresses ATP-dependent catalytic phosphorylation, thereby modulating diverse kinase-mediated signaling pathways and downstream cellular functions. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(199.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 64 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.