CAS No. 1982372-88-2
| IUPAC Name | 6,7-dichloro-N-cyclopentyl-4-pyridin-4-ylphthalazin-1-amine | |
|---|---|---|
| CAS Number | 1982372-88-2 | |
| Molecular Formula |
C18H16Cl2N4 |
|
| Molecular Weight (MW) | 359.25 | |
| SMILES | C1CCC(C1)NC2=NN=C(C3=CC(=C(C=C32)Cl)Cl)C4=CC=NC=C4 | |
| InChIKey | ABGOSOMRWSYAOB-UHFFFAOYSA-N |
A-196 is a selective inhibitor of SUV420H1 (IC50 = 0.025 μM) and SUV420H2 (IC50 = 0.144 μM), displaying over 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. By blocking SUV420H1 and SUV420H2 activity, A-196 inhibits histone H4 lysine 20 dimethylation and trimethylation in cells. This disruption alters higher-order chromatin organization and regulates downstream cellular processes, including DNA double-strand break repair and genome stability. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(41.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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