CAS No. 1235034-55-5
Batch:
Purity:99.03
Chemical Structure
Check the
A-1155463
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]-5-[3-[4-[3-(dimethylamino)prop-1-ynyl]-2-fluorophenoxy]propyl]-1,3-thiazole-4-carboxylic acid | |
|---|---|---|
| CAS Number | 1235034-55-5 | |
| Molecular Formula |
C35H32FN5O4S2 |
|
| Molecular Weight (MW) | 669.79 | |
| InChIKey | SOYCFODXNRVBTI-UHFFFAOYSA-N |
A-1155463 is a highly potent and selective BCL-XL inhibitor with an ECofin H146 cells. Selective target inhibition disrupts anti-apoptotic BCL-XL interactions, promoting mitochondrial outer membrane permeabilization and triggering caspase activation. Downstream, these apoptotic pathway alterations lead to selective induction of programmed cell death in BCL-XL-dependent tumor cells and tumor growth inhibition in xenograft models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(149.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.