CAS No. 122883-93-6
| IUPAC Name | 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one;hydrochloride | |
|---|---|---|
| CAS Number | 122883-93-6 | |
| Molecular Formula |
C21H21ClN4OS·HCl |
|
| Molecular Weight (MW) | 449.4 | |
| SMILES | C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54.Cl | |
| InChIKey | NZDBKBRIBJLNNT-UHFFFAOYSA-N |
Ziprasidone HCl is a potent serotonin and dopamine receptor antagonist. It selectively targets serotonin 5-HT2A and dopamine D2 receptors with high affinity, while also acting as an agonist at 5-HT1A receptors. Through inhibition of 5-HT2A and D2 receptor-mediated signaling pathways, Ziprasidone modulates downstream neurochemical release and intracellular cascade signaling, thereby suppressing dopamine-driven neuronal hyperresponsiveness and regulating neurotransmitter homeostasis. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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