CAS No. 7481-89-2
Batch:
Purity:99.95
Chemical Structure
Check the
Zalcitabine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | |
|---|---|---|
| CAS Number | 7481-89-2 | |
| Molecular Formula |
C9H13N3O3 |
|
| Molecular Weight (MW) | 211.22 | |
| SMILES | C1CC(OC1CO)N2C=CC(=NC2=O)N | |
| InChIKey | WREGKURFCTUGRC-POYBYMJQSA-N |
Zalcitabine is a pyrimidine nucleoside analog and HIV reverse transcriptase inhibitor (NARTI). As a deoxycytidine derivative lacking a 3'-hydroxyl group, zalcitabine is intracellularly phosphorylated in T cells into its active metabolite, dideoxycytidine triphosphate (ddCTP). Active ddCTP serves as an alternative substrate for viral reverse transcriptase and incorporates into nascent viral DNA, resulting in DNA chain termination and inhibition of retroviral replication. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 42 mg/mL |
| DMSO |
8 mg/mL
(37.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
| Water | 42 mg/mL |
| DMSO |
30 mg/mL
(142.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
| Water | 42 mg/mL |
| DMSO |
7 mg/mL
(33.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
| DMSO |
42 mg/mL
(198.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 42 mg/mL |
| Ethanol | Insoluble |
| DMSO |
42 mg/mL
(198.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 42 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.