CAS No. 1349796-36-6

Batch: Purity:99.12
Check CoA
Voxtalisib (XL765) Analogue Chemical Structure
Chemical Structure
Check the Voxtalisib (XL765) Analogue product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[4-[[3-(3,5-dimethoxyanilino)quinoxalin-2-yl]sulfamoyl]phenyl]-3-methoxy-4-methylbenzamide
CAS Number 1349796-36-6
Molecular Formula

C31H29N5O6S
Molecular Weight (MW) 599.66
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4N=C3NC5=CC(=CC(=C5)OC)OC)OC
InChIKey HJSSPYJVWLTYHG-UHFFFAOYSA-N

Biological Activity

Voxtalisib (XL765) Analogue is a dual inhibitor targeting phosphoinositide 3-kinase (PI3K) isoforms p110α, p110β, p110γ, and p110δ, as well as mammalian target of rapamycin (mTOR). By suppressing the downstream AKT/mTOR signaling axis, it blocks tumor cell survival and proliferation signaling pathways. Consequently, inhibition of this pathway reduces cell viability and suppresses growth in preclinical tumor models across multiple cancer types. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 12 mg/mL (20.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.

Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.

Reference

[1] Engelman JA. Nat Rev Cancer. 2009;9(8):550-62.

[2] Fruman DA, et al. Cell. 2017;170(4):605-635.

Jump to

Note: Technical data last updated: Sep 1, 2026.