CAS No. 137234-62-9
| IUPAC Name | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol | |
|---|---|---|
| CAS Number | 137234-62-9 | |
| Molecular Formula |
C16H14F3N5O |
|
| Molecular Weight (MW) | 349.31 | |
| SMILES | CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O | |
| InChIKey | BCEHBSKCWLPMDN-MGPLVRAMSA-N |
Voriconazole is a triazole antifungal agent that inhibits fungal cytochrome P450-dependent 14-alpha-sterol demethylase (CYP51). By blocking CYP51, voriconazole disrupts the conversion of lanosterol to ergosterol, an essential component of the fungal cell membrane. This inhibition leads to ergosterol depletion and the accumulation of toxic methylated sterol intermediates, resulting in severe membrane damage, altered permeability, and inhibition of fungal cell growth. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(200.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
| DMSO |
70 mg/mL
(200.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 70 mg/mL |
| Water | Insoluble |
| DMSO |
70 mg/mL
(200.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 70 mg/mL |
| Water | Insoluble |
| DMSO |
70 mg/mL
(200.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.