CAS No. 348622-88-8

Batch: Purity:99.92
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UK 383367 Chemical Structure
Chemical Structure
Check the UK 383367 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide
CAS Number 348622-88-8
Molecular Formula

C15H24N4O4
Molecular Weight (MW) 324.38
SMILES C1CCC(CC1)CCCC(CC(=O)NO)C2=NC(=NO2)C(=O)N
InChIKey ARJCBSRIPGJMAD-LLVKDONJSA-N

Biological Activity

UK 383367 is a potent procollagen C-proteinase (BMP-1) inhibitor that selectively targets PCP over various matrix metalloproteinases. By blocking BMP-1-mediated processing of procollagen precursors, it impairs extracellular matrix assembly and significantly reduces insoluble collagen deposition in fibroplasia models. Additionally, the compound exhibits effective dermal skin penetration in vitro, supporting its functional role in suppressing aberrant collagen accumulation and modulating tissue remodeling.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 65 mg/mL (200.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 65 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.