CAS No. 53902-12-8

Batch: Purity:99.97
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Tranilast Chemical Structure
Chemical Structure
Check the Tranilast product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid
CAS Number 53902-12-8
Molecular Formula

C18H17NO5
Molecular Weight (MW) 327.33
SMILES COC1=C(C=C(C=C1)C=CC(=O)NC2=CC=CC=C2C(=O)O)OC
InChIKey NZHGWWWHIYHZNX-CSKARUKUSA-N

Biological Activity

Tranilast is an orally active antiallergic agent that inhibits the release of lipid mediators and inflammatory cytokines from mast cells and inflammatory leukocytes. By suppressing TGF-beta signaling pathways and downstream cellular responses, it attenuates vascular smooth muscle cell proliferation, reduces local leukocyte accumulation, and prevents neointimal hyperplasia and tissue fibrosis in models of vascular injury. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 65 mg/mL (198.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Circulation. 2002;106(2):282-282.

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Note: Technical data last updated: Sep 1, 2026.