CAS No. 948557-43-5

Batch: Purity:99.98
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Tie2 kinase inhibitor 1 Chemical Structure
Chemical Structure
Check the Tie2 kinase inhibitor 1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
CAS Number 948557-43-5
Molecular Formula

C26H21N3O2S
Molecular Weight (MW) 439.53
SMILES COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5
InChIKey SINQIEAULQKUPD-UHFFFAOYSA-N

Ordering Information

Biological Activity

Tie2 kinase inhibitor 1 is a cell-permeable pyridinylimidazole compound that acts as a potent inhibitor of Tie2 receptor tyrosine kinase. By selectively blocking Tie2 phosphorylation and kinase activity, it disrupts angiopoietin-mediated Tie2 signaling pathways. This inhibition impairs downstream endothelial cell survival, tube formation, and vascular remodeling, ultimately suppressing tumor-associated neovascularization and angiogenesis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 35 mg/mL (79.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.