CAS No. 58-46-8

Batch: Purity:99.90
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Tetrabenazine (Xenazine) Chemical Structure
Chemical Structure
Check the Tetrabenazine (Xenazine) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 58-46-8
Molecular Formula

C19H27NO3
Molecular Weight (MW) 317.42
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC

Biological Activity

Tetrabenazine is a reversible high-affinity inhibitor of vesicular monoamine transporter 2 (VMAT2) that selectively blocks presynaptic monoamine uptake into granular vesicles. VMAT2 inhibition promotes early metabolic degradation of monoamines, particularly dopamine. Additionally, tetrabenazine exhibits antagonist activity at dopamine D2 receptors, albeit with lower affinity than for VMAT2. Depleting presynaptic dopamine stores suppresses downstream dopaminergic signaling and reduces hyperkinetic movement phenotypes. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 58 mg/mL (182.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 32 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kenney C, et al. Expert Rev Neurother. 2006;6(1):7-17.

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Note: Technical data last updated: Sep 1, 2026.