CAS No. 78628-80-5
| IUPAC Name | (E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine;hydrochloride | |
|---|---|---|
| CAS Number | 78628-80-5 | |
| Molecular Formula |
C21H25N.HCl |
|
| Molecular Weight (MW) | 327.89 | |
| SMILES | CC(C)(C)C#CC=CCN(C)CC1=CC=CC2=CC=CC=C21.Cl | |
| InChIKey | BWMISRWJRUSYEX-SZKNIZGXSA-N |
Terbinafine HCl is a synthetic allylamine antifungal agent that selectively inhibits fungal squalene epoxidase in Candida albicans). By blocking squalene epoxidase, it prevents the conversion of squalene to lanosterol, thereby impairing ergosterol biosynthesis and disrupting fungal cell membrane integrity. Furthermore, terbinafine demonstrates antiangiogenic and antiproliferative activities by inducing G0/G1 phase cell cycle arrest in endothelial and cancer cells. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(198.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 65 mg/mL |
| Water | Insoluble |
| DMSO |
65 mg/mL
(198.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 65 mg/mL |
| Water | Insoluble |
| DMSO |
66 mg/mL
(201.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 66 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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