Temsirolimus (CCI-779) has been evaluated across numerous clinical trials spanning Early Phase I through Phase IV, focusing on oncology indications such as high-grade gliomas, mantle cell lymphoma, advanced endometrial carcinoma, metastatic sarcomas, and refractory solid tumors. Sponsored by academic research centers, government bodies like the National Cancer Institute, and industry partners including Pfizer, these studies encompass both completed and ongoing protocols. Currently, several clinical trials remain active or recruiting to evaluate targeted intra-arterial infusion, combination regimens, and novel drug sensitivity testing.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT04199026 | RECRUITING | Metastatic Sarcoma; Recurrent Sarcoma; Resectable Sarcoma |
M.D. Anderson Cancer Center |
2025-02-25 | |
| NCT04433572 | RECRUITING | Peripheral Artery Disease; Critical Limb Ischemia |
Mercator MedSystems, Inc. |
2025-07-30 | PHASE3 |
| NCT02693535 | RECRUITING | Lymphoma, Non-Hodgkin; Multiple Myeloma; Advanced Solid Tumors |
American Society of Clinical Oncology |
2016-03-14 | PHASE2 |
| NCT02389309 | ACTIVE_NOT_RECRUITING | Advanced Malignant Solid Neoplasm; Recurrent Brain Neoplasm; Recurrent Malignant Solid Neoplasm; Refractory Brain Neoplasm |
M.D. Anderson Cancer Center |
2015-10-05 | PHASE1 |
| NCT03297606 | RECRUITING | Lymphoma, Non-Hodgkin; Multiple Myeloma; Advanced Solid Tumors |
Canadian Cancer Trials Group |
2018-03-23 | PHASE2 |
| NCT01087554 | ACTIVE_NOT_RECRUITING | Advanced Cancer |
M.D. Anderson Cancer Center |
2010-03 | PHASE1 |
| NCT03203525 | TERMINATED | Advanced Malignant Neoplasm; Colorectal Carcinoma Metastatic in the Liver; Metastatic Malignant Neoplasm in the Liver; Refractory Malignant Neoplasm |
M.D. Anderson Cancer Center |
2020-06-23 | PHASE1 |
| NCT01552434 | TERMINATED | Advanced Malignant Neoplasm; Castleman Disease; Digestive System Carcinoma; Erdheim-Chester Disease; Lip and Oral Cavity Carcinoma; Lymphangioleiomyomatosis; Malignant Endocrine Neoplasm; Malignant Female Reproductive System Neoplasm; Malignant Male Reproductive System Neoplasm; Malignant Neoplasm; Malignant Respiratory Tract Neoplasm; Malignant Thoracic Neoplasm; Malignant Urinary System Neoplasm; Mesothelial Neoplasm; Metastatic Malignant Neoplasm; Metastatic Urothelial Carcinoma; Neurofibromatosis Type 2; Recurrent Adult Soft Tissue Sarcoma; Recurrent Breast Carcinoma; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Digestive System Carcinoma; Recurrent Female Reproductive System Carcinoma; Recurrent Male Reproductive System Carcinoma; Recurrent Malignant Neoplasm; Recurrent Pharyngeal Carcinoma; Recurrent Thyroid Gland Carcinoma; Refractory Malignant Neoplasm; Soft Tissue Neoplasm; Stage III Breast Cancer AJCC v7; Stage III Pharyngeal Cancer; Stage IIIA Breast Cancer AJCC v7; Stage IIIB Breast Cancer AJCC v7; Stage IIIC Breast Cancer AJCC v7; Stage IV Breast Cancer AJCC v6 and v7; Stage IV Pharyngeal Cancer; Stage IVA Pharyngeal Cancer; Stage IVB Pharyngeal Cancer; Stage IVC Pharyngeal Cancer; Thyroid Gland Neoplasm |
M.D. Anderson Cancer Center |
2012-10-16 | PHASE1 |
| NCT01187199 | ACTIVE_NOT_RECRUITING | Advanced Cancer |
M.D. Anderson Cancer Center |
2010-08-19 | PHASE1 |
| NCT02420613 | COMPLETED | Diffuse Intrinsic Pontine Glioma |
M.D. Anderson Cancer Center |
2015-10-05 | PHASE1 |
| NCT01529593 | TERMINATED | Advanced Cancers |
M.D. Anderson Cancer Center |
2012-03-26 | PHASE1 |
| NCT05773326 | TERMINATED | High Grade Glioma; Glioma; Glioma, Malignant; Glioblastoma |
Nader Sanai |
2023-05-15 | EARLY_PHASE1 |
| NCT02446431 | RECRUITING | Solid Tumor |
Miller Children's & Women's Hospital Long Beach |
2014-07 | EARLY_PHASE1 |
| NCT02567435 | ACTIVE_NOT_RECRUITING | Alveolar Rhabdomyosarcoma; Botryoid-Type Embryonal Rhabdomyosarcoma; Embryonal Rhabdomyosarcoma; Rhabdomyosarcoma; Sclerosing Rhabdomyosarcoma; Spindle Cell Rhabdomyosarcoma |
National Cancer Institute (NCI) |
2016-06-01 | PHASE3 |
| NCT05773326 | Recruiting | High Grade Glioma|Glioma|Glioma Malignant|Glioblastoma |
Nader Sanai|Barrow Neurological Institute|Ivy Brain Tumor Center|St. Joseph''s Hospital and Medical Center Phoenix |
2023-05-15 | Early Phase 1 |
| NCT03158389 | COMPLETED | Glioblastoma, Adult |
University Hospital Heidelberg |
2018-05-07 | PHASE1; PHASE2 |
| NCT03571438 | UNKNOWN | Kidney Cancer |
University Hospital, Grenoble |
2017-10-16 | |
| NCT01143779 | COMPLETED | Advanced Cancer |
M.D. Anderson Cancer Center |
2010-06 | PHASE1 |
| NCT03942601 | TERMINATED | Peripheral Arterial Disease |
Mercator MedSystems, Inc. |
2019-10-01 | PHASE2 |
| NCT02908035 | UNKNOWN | Chronic Limb Ischemia |
Mercator MedSystems, Inc. |
2017-03-03 | PHASE2 |
| NCT00980460 | COMPLETED | PRETEXT I Hepatoblastoma; PRETEXT II Hepatoblastoma; PRETEXT III Hepatoblastoma; PRETEXT IV Hepatoblastoma |
National Cancer Institute (NCI) |
2009-09-15 | PHASE3 |
| NCT01596140 | COMPLETED | Advanced Cancer; Solid Tumor |
M.D. Anderson Cancer Center |
2012-12-18 | PHASE1 |
| NCT01614197 | COMPLETED | Lymphoblastic Leukemia, Acute, Childhood; Lymphoblastic Lymphoma; Peripheral T-cell Lymphoma |
Therapeutic Advances in Childhood Leukemia Consortium |
2015-07-03 | PHASE1 |
| NCT01392183 | COMPLETED | Kidney Cancer |
M.D. Anderson Cancer Center |
2012-10-24 | PHASE2 |
| NCT00761644 | COMPLETED | Advanced Cancer |
M.D. Anderson Cancer Center |
2008-08-21 | PHASE1 |
| NCT01051557 | COMPLETED | Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Diffuse Astrocytoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Adult Oligodendroglioma; Recurrent Adult Brain Neoplasm |
National Cancer Institute (NCI) |
2010-01-27 | PHASE1; PHASE2 |
| NCT01517243 | COMPLETED | Metastatic Renal Cell Carcinoma |
Dartmouth-Hitchcock Medical Center |
2010-09-22 | PHASE2 |
| NCT01767194 | COMPLETED | Ganglioneuroblastoma; Recurrent Neuroblastoma |
National Cancer Institute (NCI) |
2013-02-12 | PHASE2 |
| NCT01375829 | ACTIVE_NOT_RECRUITING | Adult Solid Neoplasm |
National Cancer Institute (NCI) |
2011-06-27 | PHASE1 |
| NCT01653067 | UNKNOWN | Diffuse Large B-Cell Lymphoma |
Mathias Witzens-Harig |
2012-09 | PHASE2 |
| NCT01016769 | COMPLETED | Squamous Cell Cancer; Head and Neck Cancer |
Memorial Sloan Kettering Cancer Center |
2009-11 | PHASE1; PHASE2 |
| NCT01025453 | COMPLETED | Thyroid Cancer |
Memorial Sloan Kettering Cancer Center |
2009-12-01 | PHASE2 |
| NCT01076543 | COMPLETED | AIDS-Related Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Follicular Lymphoma; Recurrent Lymphoplasmacytic Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Non-Hodgkin Lymphoma; Recurrent T-Cell Non-Hodgkin Lymphoma; Waldenstrom Macroglobulinemia |
National Cancer Institute (NCI) |
2010-04-15 | PHASE1; PHASE2 |
| NCT00610493 | COMPLETED | Advanced Cancer |
M.D. Anderson Cancer Center |
2008-01-25 | PHASE1 |
| NCT02423954 | TERMINATED | Advanced Cancer; Pancreatic Cancer; Renal Cell Cancer; Non Small Cell Lung Cancer; Colorectal Carcinoma; Endometrial; Uterine |
Western Regional Medical Center |
2015-04 | PHASE1; PHASE2 |
| NCT02238496 | COMPLETED | Brain Tumor, Recurrent; Glioblastoma; Anaplastic Astrocytoma; Anaplastic Oligodendroglioma; Mixed Glioma |
Andrew B Lassman, MD |
2014-12-08 | PHASE1 |
| NCT02343718 | COMPLETED | Recurrent Lymphoma; Refractory Lymphoma; Solid Tumours; Central Nervous System |
Canadian Cancer Trials Group |
2015-06-24 | PHASE1 |
| NCT01078142 | COMPLETED | Follicular Lymphoma; Mantle Cell Lymphoma |
Georg Hess, MD |
2010-02-02 | PHASE1; PHASE2 |
| NCT02560012 | TERMINATED | Carcinoma, Renal Cell |
The University of Texas Health Science Center, Houston |
2016-01-04 | PHASE2 |
| NCT01611116 | COMPLETED | Acute Myeloblastic Leukemia |
Goethe University |
2012-05 | PHASE2 |
| NCT01010126 | COMPLETED | Adult Hepatocellular Carcinoma; Advanced Adult Hepatocellular Carcinoma; Endometrial Serous Adenocarcinoma; Localized Non-Resectable Adult Liver Carcinoma; Lung Carcinoid Tumor; Malignant Pancreatic Gastrinoma; Malignant Pancreatic Glucagonoma; Malignant Pancreatic Insulinoma; Malignant Pancreatic Somatostatinoma; Metastatic Digestive System Neuroendocrine Tumor G1; Ovarian Carcinosarcoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Surface Papillary Adenocarcinoma; Pancreatic Alpha Cell Adenoma; Pancreatic Beta Cell Adenoma; Pancreatic Delta Cell Adenoma; Pancreatic G-Cell Adenoma; Pancreatic Polypeptide Tumor; Recurrent Adult Liver Carcinoma; Recurrent Digestive System Neuroendocrine Tumor G1; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Pancreatic Neuroendocrine Carcinoma; Recurrent Primary Peritoneal Carcinoma; Recurrent Uterine Corpus Carcinoma; Regional Digestive System Neuroendocrine Tumor G1; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Cancer; Stage IIIA Primary Peritoneal Cancer; Stage IIIA Uterine Corpus Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Cancer; Stage IIIB Primary Peritoneal Cancer; Stage IIIB Uterine Corpus Cancer; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Cancer; Stage IIIC Primary Peritoneal Cancer; Stage IIIC Uterine Corpus Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer; Stage IVA Uterine Corpus Cancer; Stage IVB Uterine Corpus Cancer; Uterine Carcinosarcoma |
National Cancer Institute (NCI) |
2009-09-08 | PHASE2 |
| NCT01049841 | COMPLETED | Pediatric Solid Tumors |
Memorial Sloan Kettering Cancer Center |
2010-01 | PHASE1 |
| NCT00729586 | COMPLETED | Endometrial Carcinoma; Recurrent Uterine Corpus Carcinoma; Stage IIIA Uterine Corpus Cancer; Stage IIIB Uterine Corpus Cancer; Stage IIIC1 Uterine Corpus Cancer; Stage IIIC2 Uterine Corpus Cancer; Stage IVA Uterine Corpus Cancer; Stage IVB Uterine Corpus Cancer |
National Cancer Institute (NCI) |
2008-09 | PHASE2 |
| NCT01326468 | WITHDRAWN | Head and Neck Cancer |
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University |
2011-12-08 | |
| NCT00838955 | TERMINATED | Hodgkin's Lymphoma |
Loyola University |
2009-01 | PHASE2 |
| NCT01827267 | COMPLETED | HER2-mutant Non-Small Cell Lung Cancer |
Puma Biotechnology, Inc. |
2013-07-01 | PHASE2 |
| NCT01111825 | COMPLETED | Breast Cancer |
Puma Biotechnology, Inc. |
2010-04 | PHASE1; PHASE2 |
| NCT01535989 | COMPLETED | B-cell Lymphoma Refractory |
Cristiana Sessa |
2011-12 | PHASE1 |
| NCT01183663 | COMPLETED | Advanced Cancers |
M.D. Anderson Cancer Center |
2010-08 | PHASE1 |
| NCT01687673 | COMPLETED | Hepatocellular Carcinoma |
University of California, San Francisco |
2012-10-05 | PHASE2 |
| NCT01251458 | COMPLETED | Inoperable HCC |
Chinese University of Hong Kong |
2009-10 | PHASE1; PHASE2 |
| NCT01180049 | COMPLETED | Non-Hodgkin's Lymphoma |
Pfizer |
2011-03 | PHASE4 |
| NCT01625156 | COMPLETED | Adult Solid Neoplasm |
National Cancer Institute (NCI) |
2012-05 | PHASE1 |
| NCT01946529 | COMPLETED | Desmoplastic Small Round Cell Tumor; Ewing Sarcoma of Bone or Soft Tissue; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor |
St. Jude Children's Research Hospital |
2013-12-27 | PHASE2 |
| NCT01174199 | TERMINATED | Prostate Cancer; Adenocarcinoma of the Prostate; Hormone-resistant Prostate Cancer; Recurrent Prostate Cancer; Stage IV Prostate Cancer |
Roswell Park Cancer Institute |
2012-02 | PHASE1 |
| NCT01396408 | ACTIVE_NOT_RECRUITING | Advanced Rare Tumours |
Canadian Cancer Trials Group |
2012-02-09 | PHASE2 |
| NCT01264341 | TERMINATED | Kidney Cancer |
Hellenic Cooperative Oncology Group |
2010-12 | PHASE2 |
| NCT01646021 | COMPLETED | Mantle Cell Lymphoma |
Janssen Research & Development, LLC |
2012-12-10 | PHASE3 |
| NCT01222715 | COMPLETED | Adult Rhabdomyosarcoma; Childhood Alveolar Rhabdomyosarcoma; Childhood Pleomorphic Rhabdomyosarcoma; Childhood Rhabdomyosarcoma With Mixed Embryonal and Alveolar Features; Previously Treated Childhood Rhabdomyosarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Childhood Rhabdomyosarcoma |
National Cancer Institute (NCI) |
2010-10 | PHASE2 |
| NCT01798446 | COMPLETED | Renal Cell Carcinoma; Nonclear Cell; Temsirolimus Resistance |
Seoul National University Hospital |
2013-02 | PHASE2 |
| NCT01460979 | COMPLETED | Genital Diseases, Female; Ovarian Diseases; Ovarian Neoplasms; Endometrial Neoplasms |
AGO Study Group |
2011-10 | PHASE2 |
| NCT01369433 | TERMINATED | Solid Tumors |
AVEO Pharmaceuticals, Inc. |
2010-06 | |
| NCT00782275 | COMPLETED | Renal Cell Carcinoma; Kidney Cancer |
Beth Israel Deaconess Medical Center |
2009-04 | PHASE2 |
| NCT01403415 | COMPLETED | Childhood B Acute Lymphoblastic Leukemia; Childhood T Acute Lymphoblastic Leukemia; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Lymphoblastic Lymphoma |
National Cancer Institute (NCI) |
2011-09 | PHASE1 |
| NCT01902160 | COMPLETED | Recurrent Adult Hodgkin Lymphoma |
National Cancer Institute (NCI) |
2013-09 | PHASE1 |
| NCT01206140 | COMPLETED | Recurrent Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma |
National Cancer Institute (NCI) |
2010-10 | PHASE2 |
| NCT00977574 | ACTIVE_NOT_RECRUITING | Endometrial Adenocarcinoma; Endometrial Adenosquamous Carcinoma; Endometrial Clear Cell Adenocarcinoma; Endometrial Serous Adenocarcinoma; Recurrent Malignant Uterine Corpus Neoplasm; Stage IIIA Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage; Stage IIIB Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage; Stage IIIC Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage; Stage IVA Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage; Stage IVB Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage |
National Cancer Institute (NCI) |
2009-09-14 | PHASE2 |
| NCT01196429 | COMPLETED | Ovarian Clear Cell Cystadenocarcinoma; Stage III Ovarian Cancer; Stage IV Ovarian Cancer |
National Cancer Institute (NCI) |
2010-08 | PHASE2 |
| NCT01381692 | COMPLETED | Recurrent Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Non-Hodgkin Lymphoma; Recurrent Small Lymphocytic Lymphoma; Recurrent Waldenstrom Macroglobulinemia; Refractory Follicular Lymphoma; Refractory Mantle Cell Lymphoma; Refractory Marginal Zone Lymphoma; Refractory Non-Hodgkin Lymphoma; Refractory Small Lymphocytic Lymphoma |
National Cancer Institute (NCI) |
2011-07-20 | PHASE1; PHASE2 |
| NCT01827943 | COMPLETED | Relapsed Bladder Cancer |
Institut Bergonié |
2009-06 | PHASE2 |
| NCT02215720 | COMPLETED | Patients With Advanced or Metastatic Solid Tumors |
Gustave Roussy, Cancer Campus, Grand Paris |
2011-04-26 | PHASE1 |
| NCT00770263 | COMPLETED | Solid Tumors |
Washington University School of Medicine |
2009-05 | PHASE1 |
| NCT01206036 | COMPLETED | Prostatic Neoplasms |
Central European Society for Anticancer Drug Research |
2010-07 | PHASE1; PHASE2 |
| NCT01404104 | COMPLETED | Renal Cell Carcinoma |
St. Joseph's Healthcare Hamilton |
2008-09 | |
| NCT01016015 | COMPLETED | Metastatic Osteosarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Osteosarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma |
National Cancer Institute (NCI) |
2009-11 | PHASE2 |
| NCT01122615 | COMPLETED | Renal Cell Cancer; Kidney Cancer |
M.D. Anderson Cancer Center |
2010-05 | PHASE1 |
| NCT01417065 | COMPLETED | Advanced Cancer |
M.D. Anderson Cancer Center |
2010-08 | EARLY_PHASE1 |
| NCT00877773 | TERMINATED | Advanced Cancers |
M.D. Anderson Cancer Center |
2009-04 | PHASE1; PHASE2 |
| NCT01614301 | UNKNOWN | Advanced Melanoma |
University of Regensburg |
2012-05 | PHASE1; PHASE2 |
| NCT01614795 | COMPLETED | Childhood Alveolar Soft Part Sarcoma; Childhood Angiosarcoma; Childhood Epithelioid Sarcoma; Childhood Fibrosarcoma; Childhood Gliosarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Peripheral Nerve Sheath Tumor; Childhood Synovial Sarcoma; Previously Treated Childhood Rhabdomyosarcoma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Osteosarcoma; Rhabdomyosarcoma |
National Cancer Institute (NCI) |
2012-06-18 | PHASE2 |
| NCT01529138 | COMPLETED | Cancer |
Emory University |
2011-10 | PHASE1 |
| NCT02093598 | COMPLETED | Carcinoma, Endometrioid; mTOR Protein |
MedSIR |
2012-05 | PHASE2 |
| NCT00378703 | COMPLETED | Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Carcinoma; Stage IV Renal Cell Cancer AJCC v7 |
National Cancer Institute (NCI) |
2007-09-14 | PHASE2 |
| NCT01548482 | COMPLETED | Adult Solid Neoplasm; Lung Carcinoid Tumor; Recurrent Digestive System Neuroendocrine Tumor G1; Recurrent Renal Cell Carcinoma; Recurrent Uterine Corpus Sarcoma; Stage III Renal Cell Cancer; Stage IIIB Uterine Sarcoma; Stage IIIC Uterine Sarcoma; Stage IV Renal Cell Cancer; Stage IVA Uterine Sarcoma; Stage IVB Uterine Sarcoma |
National Cancer Institute (NCI) |
2012-03 | PHASE1 |
| NCT01256385 | COMPLETED | Recurrent Hypopharyngeal Squamous Cell Carcinoma; Recurrent Laryngeal Squamous Cell Carcinoma; Recurrent Laryngeal Verrucous Carcinoma; Recurrent Lip and Oral Cavity Squamous Cell Carcinoma; Recurrent Metastatic Squamous Cell Carcinoma in the Neck With Occult Primary; Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma; Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma; Recurrent Oral Cavity Verrucous Carcinoma; Recurrent Oropharyngeal Squamous Cell Carcinoma; Recurrent Salivary Gland Carcinoma; Salivary Gland Squamous Cell Carcinoma; Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary; Stage IV Hypopharyngeal Squamous Cell Carcinoma; Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma; Stage IVA Laryngeal Squamous Cell Carcinoma; Stage IVA Laryngeal Verrucous Carcinoma; Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma; Stage IVA Major Salivary Gland Carcinoma; Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma; Stage IVA Oral Cavity Verrucous Carcinoma; Stage IVA Oropharyngeal Squamous Cell Carcinoma; Stage IVB Laryngeal Squamous Cell Carcinoma; Stage IVB Laryngeal Verrucous Carcinoma; Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma; Stage IVB Major Salivary Gland Carcinoma; Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma; Stage IVB Oral Cavity Verrucous Carcinoma; Stage IVB Oropharyngeal Squamous Cell Carcinoma; Stage IVC Laryngeal Squamous Cell Carcinoma; Stage IVC Laryngeal Verrucous Carcinoma; Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma; Stage IVC Major Salivary Gland Carcinoma; Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma; Stage IVC Oral Cavity Verrucous Carcinoma; Stage IVC Oropharyngeal Squamous Cell Carcinoma; Tongue Carcinoma |
National Cancer Institute (NCI) |
2010-11 | PHASE2 |
| NCT01019434 | COMPLETED | Brain and Central Nervous System Tumors |
European Organisation for Research and Treatment of Cancer - EORTC |
2009-10 | PHASE2 |
| NCT01335074 | WITHDRAWN | Hepatocellular Carcinoma |
Philipps University Marburg |
2011-04 | PHASE1; PHASE2 |
| NCT00942747 | UNKNOWN | Recurrent or Refractory Primary CNS Lymphoma |
Charite University, Berlin, Germany |
2009-07 | PHASE2 |
| NCT01141244 | COMPLETED | Unspecified Childhood Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2010-06 | PHASE1 |
| NCT01281917 | COMPLETED | Non-Hodgkins Lymphoma |
University of Wisconsin, Madison |
2011-02 | PHASE2 |
| NCT00699491 | COMPLETED | Male Breast Carcinoma; Recurrent Breast Carcinoma; Stage IV Breast Cancer AJCC v6 and v7 |
National Cancer Institute (NCI) |
2008-10-31 | PHASE1; PHASE2 |
| NCT01065662 | COMPLETED | Endometrial Cancer; Ovarian Cancer; Cervical Cancer; Fallopian Tube Cancer; Peritoneal Cancer |
Susana M. Campos, MD |
2010-02 | PHASE1 |
| NCT00397982 | COMPLETED | Recurrent Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma |
National Cancer Institute (NCI) |
2008-01 | PHASE2 |
| NCT01198184 | COMPLETED | Endometrial Papillary Serous Carcinoma; Recurrent Endometrial Carcinoma; Recurrent Renal Cell Cancer; Stage III Endometrial Carcinoma; Stage III Renal Cell Cancer; Stage IV Endometrial Carcinoma; Stage IV Renal Cell Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2010-08 | PHASE1 |
| NCT00678769 | COMPLETED | Malignant Neoplasm |
National Cancer Institute (NCI) |
2008-05 | PHASE1 |
| NCT01111448 | TERMINATED | Myelodysplastic Syndrome |
Technische Universität Dresden |
2010-04 | PHASE2 |
| NCT01050985 | COMPLETED | Advanced Solid Tumors |
Georgetown University |
2010-07 | PHASE1 |
| NCT00329719 | COMPLETED | Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Neoplasm |
National Cancer Institute (NCI) |
2006-03-24 | PHASE1; PHASE2 |
| NCT00919035 | COMPLETED | Prostate Cancer |
Oncology Specialists, S.C. |
2009-06 | PHASE2 |
| NCT01026623 | COMPLETED | Hormone-Resistant Prostate Cancer; Prostate Adenocarcinoma; Recurrent Prostate Carcinoma; Stage IV Prostate Cancer |
National Cancer Institute (NCI) |
2009-10 | PHASE1; PHASE2 |
| NCT01712828 | COMPLETED | Healthy |
Celgene |
2012-10-01 | PHASE1 |
| NCT00921310 | TERMINATED | Carcinoma, Non-Small-Cell Lung |
Washington University School of Medicine |
2009-09 | PHASE1; PHASE2 |
| NCT01155258 | COMPLETED | Extensive Stage Small Cell Lung Cancer; Hereditary Paraganglioma; Male Breast Cancer; Malignant Paraganglioma; Metastatic Gastrointestinal Carcinoid Tumor; Metastatic Pheochromocytoma; Pancreatic Polypeptide Tumor; Recurrent Breast Cancer; Recurrent Cervical Cancer; Recurrent Endometrial Carcinoma; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Islet Cell Carcinoma; Recurrent Neuroendocrine Carcinoma of the Skin; Recurrent Non-small Cell Lung Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Pheochromocytoma; Recurrent Prostate Cancer; Recurrent Renal Cell Cancer; Recurrent Small Cell Lung Cancer; Recurrent Uterine Sarcoma; Regional Gastrointestinal Carcinoid Tumor; Regional Pheochromocytoma; Stage III Cervical Cancer; Stage III Endometrial Carcinoma; Stage III Neuroendocrine Carcinoma of the Skin; Stage III Ovarian Epithelial Cancer; Stage III Ovarian Germ Cell Tumor; Stage III Prostate Cancer; Stage III Renal Cell Cancer; Stage III Uterine Sarcoma; Stage IIIA Breast Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Breast Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer; Stage IV Endometrial Carcinoma; Stage IV Neuroendocrine Carcinoma of the Skin; Stage IV Non-small Cell Lung Cancer; Stage IV Ovarian Epithelial Cancer; Stage IV Ovarian Germ Cell Tumor; Stage IV Prostate Cancer; Stage IV Renal Cell Cancer; Stage IV Uterine Sarcoma; Stage IVA Cervical Cancer; Stage IVB Cervical Cancer; Thyroid Gland Medullary Carcinoma |
University of Southern California |
2010-06 | PHASE1 |
| NCT01015664 | TERMINATED | Squamous Cell Carcinoma of the Head and Neck |
University of Tennessee Cancer Institute |
2010-02 | PHASE1; PHASE2 |
| NCT01567930 | UNKNOWN | Unresectable or Metastatic Hepatocellular Carcinoma |
University of Tennessee Cancer Institute |
2010-02 | PHASE2 |
| NCT01204450 | TERMINATED | Brain and Central Nervous System Tumors; Neuroblastoma; Sarcoma; Unspecified Childhood Solid Tumor, Protocol Specific |
UNC Lineberger Comprehensive Cancer Center |
2009-11 | PHASE1 |
| NCT00770731 | COMPLETED | Advanced Cancer |
M.D. Anderson Cancer Center |
2008-09 | PHASE1 |
| NCT00880282 | COMPLETED | Unspecified Childhood Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2009-04 | PHASE1 |
| NCT01008917 | COMPLETED | Hepatocellular Carcinoma |
University of California, San Francisco |
2009-11-17 | PHASE1 |
| NCT01653067 | Unknown status | Diffuse Large B-Cell Lymphoma |
Mathias Witzens-Harig|Johannes Gutenberg University Mainz|Technical University of Munich|Ludwig-Maximilians - University of Munich|University Hospital Ulm|University Hospital Erlangen|Charite University Berlin Germany|University Hospital Freiburg|Johann Wolfgang Goethe University Hospital|University Hospital Heidelberg |
2012-09 | Phase 2 |
| NCT01009203 | TERMINATED | Squamous Cell Carcinoma |
New Mexico Cancer Research Alliance |
2009-12 | PHASE2 |
| NCT00949325 | COMPLETED | Sarcoma |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
2009-09 | PHASE1; PHASE2 |
| NCT01026792 | COMPLETED | Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Squamous Cell Carcinoma; Recurrent Cervical Carcinoma; Stage IIIA Cervical Cancer; Stage IIIB Cervical Cancer; Stage IVA Cervical Cancer; Stage IVB Cervical Cancer |
National Cancer Institute (NCI) |
2009-12 | PHASE2 |
| NCT00887640 | TERMINATED | Prostate Cancer |
Duke University |
2009-07 | PHASE2 |
| NCT01246817 | UNKNOWN | Renal Cell Cancer |
Radboud University Medical Center |
2009-08 | PHASE2 |
| NCT01281943 | WITHDRAWN | Liver Neoplasms |
Washington University School of Medicine |
2011-06 | PHASE2 |
| NCT00979966 | COMPLETED | Non-clear Cell Renal Cell Cancer |
Central European Society for Anticancer Drug Research |
2009-07 | PHASE2 |
| NCT00775593 | COMPLETED | Leukemia |
Gruppo Italiano Malattie EMatologiche dell'Adulto |
2008-12 | PHASE2 |
| NCT01166126 | TERMINATED | Mucosal Melanoma; Recurrent Melanoma; Stage IV Melanoma |
National Cancer Institute (NCI) |
2010-10 | PHASE2 |
| NCT00998036 | COMPLETED | Triple Negative Breast Cancer |
Columbia University |
2009-09 | PHASE1 |
| NCT02093598 | Completed | Carcinoma Endometrioid|mTOR Protein |
MedSIR |
2012-05 | Phase 2 |
| NCT00909831 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Abramson Cancer Center at Penn Medicine |
2008-10 | PHASE1 |
| NCT01182883 | WITHDRAWN | Brain Stem Neoplasms; Glioma; Pinealoma |
National Cancer Institute (NCI) |
2010-07-28 | PHASE1 |
| NCT00631371 | COMPLETED | Renal Cell Carcinoma |
Pfizer |
2008-04 | PHASE3 |
| NCT01170052 | WITHDRAWN | Mantle Cell Lymphoma |
Charite University, Berlin, Germany |
2010-05 | PHASE1; PHASE2 |
| NCT00787969 | COMPLETED | Lymphoma |
Alliance for Clinical Trials in Oncology |
2009-04 | PHASE1 |
| NCT01020305 | TERMINATED | Prostate Cancer; Prostatic Neoplasms; Castrate-resistant Prostate Cancer (CRPC); Androgen-insensitive Prostate Cancer; Hormone-refractory Prostate Cancer; Metastatic Disease |
Sandy Srinivas |
2009-10 | PHASE1; PHASE2 |
| NCT01061606 | TERMINATED | Recurrent Uterine Sarcoma; Uterine Carcinosarcoma |
National Cancer Institute (NCI) |
2010-01 | PHASE2 |
| NCT01172769 | COMPLETED | Head and Neck Squamous Cell Carcinoma |
Hannover Medical School |
2010-06 | PHASE2 |
| NCT01378377 | TERMINATED | Advanced Solid Tumor |
EMD Serono |
2011-05-27 | PHASE1 |
| NCT01072890 | COMPLETED | Solid Tumors |
University of California, Davis |
2010-02 | PHASE1 |
| NCT01851408 | WITHDRAWN | Melanoma; Recurrent Melanoma; Stage III Melanoma; Stage IV Melanoma |
National Cancer Institute (NCI) |
2006-04 | PHASE2 |
| NCT00982631 | UNKNOWN | Advanced/Recurrent Breast Cancer; Endometrial Cancer; Ovarian Cancer |
Radboud University Medical Center |
2009-06 | PHASE1 |
| NCT00398515 | COMPLETED | Refractory Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma |
National Cancer Institute (NCI) |
2007-03 | PHASE1 |
| NCT00619268 | COMPLETED | Metastatic Renal Cell Carcinoma |
Centre Leon Berard |
2008-02 | PHASE2 |
| NCT00349206 | COMPLETED | Melanoma; Recurrent Melanoma; Stage III Melanoma; Stage IV Melanoma |
National Cancer Institute (NCI) |
2006-04 | PHASE1 |
| NCT00429793 | COMPLETED | Fallopian Tube Cancer; Primary Peritoneal Cavity Cancer; Recurrent Ovarian Epithelial Cancer |
National Cancer Institute (NCI) |
2007-02 | PHASE2 |
| NCT00408655 | COMPLETED | Ovarian Sarcoma; Ovarian Stromal Cancer; Recurrent Endometrial Carcinoma; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Stage III Endometrial Carcinoma; Stage III Ovarian Epithelial Cancer; Stage III Ovarian Germ Cell Tumor; Stage IV Endometrial Carcinoma; Stage IV Ovarian Epithelial Cancer; Stage IV Ovarian Germ Cell Tumor; Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2007-02 | PHASE1 |
| NCT00474786 | COMPLETED | Renal Cell Carcinoma |
Pfizer |
2007-09 | PHASE3 |
| NCT01083368 | COMPLETED | Prostate Cancer |
Case Comprehensive Cancer Center |
2009-01 | PHASE1; PHASE2 |
| NCT00996346 | TERMINATED | Sarcoma |
New Mexico Cancer Research Alliance |
2009-10 | PHASE1 |
| NCT00926107 | TERMINATED | Ovarian Cancer |
Hellenic Cooperative Oncology Group |
2009-06 | PHASE2 |
| NCT00723255 | COMPLETED | Recurrent Endometrial Carcinoma |
National Cancer Institute (NCI) |
2008-09 | PHASE2 |
| NCT00703170 | COMPLETED | Resistant Solid Malignancies |
Washington University School of Medicine |
2008-03 | PHASE1 |
| NCT00838539 | COMPLETED | Neoplasms; Malignant Carcinoma |
Puma Biotechnology, Inc. |
2009-04 | PHASE1 |
| NCT00796796 | COMPLETED | Carcinoma, Non-Small-Cell Lung |
Washington University School of Medicine |
2009-03 | PHASE1 |
| NCT00703625 | COMPLETED | Resistant Solid Malignancies |
Washington University School of Medicine |
2008-03-08 | PHASE1 |
| NCT00494091 | COMPLETED | Advanced Renal Cell Carcinoma |
Pfizer |
2007-02 | PHASE2 |
| NCT01079286 | COMPLETED | Renal Cell Cancer; Cancer |
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
2009-06 | PHASE1 |
| NCT00093782 | COMPLETED | Metastatic Gastrointestinal Carcinoid Tumor; Pulmonary Carcinoid Tumor; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Islet Cell Carcinoma |
National Cancer Institute (NCI) |
2003-12 | PHASE2 |
| NCT00827684 | COMPLETED | Metastatic Colorectal Cancer |
Vejle Hospital |
2009-03 | PHASE2 |
| NCT00483262 | COMPLETED | Multiple Myeloma |
Dana-Farber Cancer Institute |
2007-05 | PHASE1; PHASE2 |
| NCT00281957 | COMPLETED | Recurrent Melanoma; Stage IV Melanoma |
National Cancer Institute (NCI) |
2007-08 | PHASE2 |
| NCT01079767 | TERMINATED | Liver Cancer |
Federation Francophone de Cancerologie Digestive |
2010-01 | PHASE2 |
| NCT00316849 | COMPLETED | Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma |
National Cancer Institute (NCI) |
2006-05 | PHASE1 |
| NCT00784914 | COMPLETED | Brain and Central Nervous System Tumors; Metastatic Cancer |
City of Hope Medical Center |
2008-06 | PHASE1 |
| NCT00563147 | COMPLETED | Renal Cell Carcinoma |
AVEO Pharmaceuticals, Inc. |
2007-11 | PHASE1 |
| NCT00600496 | COMPLETED | Breast Cancer; Breast Neoplasms; Colon Cancer; Colonic Cancer; Colon Neoplasms; Lung Cancer; Melanoma; Kidney Cancer |
AstraZeneca |
2007-12-14 | PHASE1 |
| NCT00693433 | COMPLETED | Refractory Multiple Myeloma; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma |
National Cancer Institute (NCI) |
2008-12 | PHASE1 |
| NCT00112476 | COMPLETED | Recurrent Melanoma; Recurrent Renal Cell Cancer; Stage IV Melanoma; Stage IV Renal Cell Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2005-03 | PHASE1 |
| NCT00101088 | TERMINATED | Accelerated Phase Chronic Myelogenous Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Phase Chronic Myelogenous Leukemia; Relapsing Chronic Myelogenous Leukemia |
National Cancer Institute (NCI) |
2005-04 | PHASE1 |
| NCT00949026 | WITHDRAWN | Brain Neoplasms |
Emory University |
2009-07 | PHASE1 |
| NCT00112736 | COMPLETED | Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Diffuse Astrocytoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Adult Pilocytic Astrocytoma; Adult Pineal Gland Astrocytoma; Adult Subependymal Giant Cell Astrocytoma; Recurrent Adult Brain Tumor |
National Cancer Institute (NCI) |
2005-04 | PHASE1; PHASE2 |
| NCT00659568 | COMPLETED | Breast Cancer; Endometrial Cancer; Kidney Cancer; Lung Cancer; Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific |
London Health Sciences Centre |
2008-03 | PHASE1 |
| NCT00335764 | COMPLETED | Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor |
National Cancer Institute (NCI) |
2006-04 | PHASE1; PHASE2 |
| NCT00800917 | COMPLETED | Glioblastoma Multiforme |
Rigshospitalet, Denmark |
2008-11 | PHASE2 |
| NCT01090466 | COMPLETED | Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer |
Cardiff University |
2008-02 | PHASE1; PHASE2 |
| NCT00593008 | TERMINATED | Pancreatic Adenocarcinoma |
Massachusetts General Hospital |
2007-10 | PHASE1 |
| NCT00593060 | COMPLETED | Colorectal Cancer; Colorectal Adenocarcinoma |
Jeffrey W. Clark, MD |
2007-11-01 | PHASE1 |
| NCT00106353 | COMPLETED | Adenocarcinoma; Neoplasms |
Pfizer |
2005-03 | PHASE1; PHASE2 |
| NCT00109967 | COMPLETED | Recurrent Mantle Cell Lymphoma |
National Cancer Institute (NCI) |
2005-05 | PHASE2 |
| NCT00523432 | COMPLETED | Genital Neoplasms, Female |
University of Chicago |
2007-08 | PHASE1 |
| NCT00808899 | TERMINATED | Neuroblastoma |
St. Jude Children's Research Hospital |
2008-12 | PHASE2 |
| NCT00072176 | COMPLETED | Endometrial Adenocarcinoma; Endometrial Adenosquamous Cell Carcinoma; Endometrial Clear Cell Carcinoma; Endometrial Papillary Serous Carcinoma; Recurrent Endometrial Carcinoma; Stage IIIA Endometrial Carcinoma; Stage IIIB Endometrial Carcinoma; Stage IIIC Endometrial Carcinoma; Stage IVA Endometrial Carcinoma; Stage IVB Endometrial Carcinoma |
National Cancer Institute (NCI) |
2004-05 | PHASE2 |
| NCT00376688 | COMPLETED | Recurrent Breast Carcinoma; Stage III Breast Cancer AJCC v7; Stage IIIA Breast Cancer AJCC v7; Stage IIIB Breast Cancer AJCC v7; Stage IIIC Breast Cancer AJCC v7; Stage IV Breast Cancer AJCC v6 and v7 |
National Cancer Institute (NCI) |
2006-07-11 | PHASE2 |
| NCT00275093 | COMPLETED | Hepatic Complications; Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2005-12 | PHASE1 |
| NCT00512668 | TERMINATED | Adenocarcinoma of the Prostate; Recurrent Prostate Cancer |
National Cancer Institute (NCI) |
2007-09 | PHASE1 |
| NCT00098501 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2004-10 | PHASE1 |
| NCT00117598 | COMPLETED | Lymphoma |
Pfizer |
2005-05 | PHASE3 |
| NCT00079235 | COMPLETED | Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer |
National Cancer Institute (NCI) |
2004-02 | PHASE2 |
| NCT00255658 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2005-09 | PHASE1 |
| NCT00079456 | COMPLETED | Refractory Multiple Myeloma; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma |
National Cancer Institute (NCI) |
2004-02 | PHASE2 |
| NCT00028028 | COMPLETED | Extensive Stage Small Cell Lung Cancer |
National Cancer Institute (NCI) |
2002-02 | PHASE2 |
| NCT00083993 | TERMINATED | Breast Neoplasms; Neoplasm Metastasis |
Wyeth is now a wholly owned subsidiary of Pfizer |
2004-05 | PHASE3 |
| NCT00022724 | COMPLETED | Brain and Central Nervous System Tumors |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
2001-08-27 | PHASE1; PHASE2 |
| NCT00071968 | COMPLETED | Prostate Cancer |
Jonsson Comprehensive Cancer Center |
2003-08 | PHASE2 |
| NCT00033267 | COMPLETED | Recurrent Mantle Cell Lymphoma |
National Cancer Institute (NCI) |
2002-04 | PHASE2 |
| NCT00087074 | COMPLETED | Gastrointestinal Stromal Tumor; Recurrent Adult Soft Tissue Sarcoma; Stage I Adult Soft Tissue Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma |
National Cancer Institute (NCI) |
2004-06 | PHASE2 |
| NCT00022464 | COMPLETED | Melanoma (Skin) |
City of Hope Medical Center |
2001-06 | PHASE2 |
| NCT00086840 | TERMINATED | Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia |
National Cancer Institute (NCI) |
2004-05 | PHASE2 |
| NCT00016328 | COMPLETED | Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor |
National Cancer Institute (NCI) |
2001-05 | PHASE2 |
| NCT00062751 | COMPLETED | Breast Neoplasms |
Wyeth is now a wholly owned subsidiary of Pfizer |
2002-12 | PHASE2 |
| NCT00075647 | COMPLETED | Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage II Pancreatic Cancer; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer |
National Cancer Institute (NCI) |
2003-12 | PHASE2 |
| NCT00045370 | COMPLETED | Kidney Cancer |
Memorial Sloan Kettering Cancer Center |
2002-04 | PHASE1 |
| NCT00003712 | COMPLETED | Brain and Central Nervous System Tumors; Metastatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
The University of Texas Health Science Center at San Antonio |
2001-01 | PHASE1 |
| NCT00788580 | WITHDRAWN | Unspecified Adult Solid Tumor, Protocol Specific |
SWOG Cancer Research Network |
PHASE1 | |
| NCT00012142 | COMPLETED | Prostate Cancer |
Jonsson Comprehensive Cancer Center |
2000-09 | PHASE2 |
| NCT00417677 | TERMINATED | Renal Cell Carcinoma |
Wyeth is now a wholly owned subsidiary of Pfizer |
2007-03 | PHASE1; PHASE2 |
| NCT00235794 | COMPLETED | Prostatic Neoplasms |
Wyeth is now a wholly owned subsidiary of Pfizer |
2004-01 |
(data from https://clinicaltrials.gov, updated on 2026-08-11)
Check the
Temsirolimus (CCI-779)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
- Temsirolimus (CCI-779) Solubility in DMSO
- Temsirolimus (CCI-779) Stock Solution
- Temsirolimus (CCI-779) Storage
- Temsirolimus (CCI-779) Stability
- Temsirolimus (CCI-779) Molecular Weight
- Temsirolimus (CCI-779) SMILES
- Temsirolimus (CCI-779) CAS Number
- Temsirolimus (CCI-779) Chemical Structure (2D and 3D)
- Temsirolimus (CCI-779) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.