CAS No. 663619-89-4
| IUPAC Name | 9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one | |
|---|---|---|
| CAS Number | 663619-89-4 | |
| Molecular Formula |
C21H24N4O2 |
|
| Molecular Weight (MW) | 364.44 | |
| SMILES | CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3)N4CCOCC4 | |
| InChIKey | CPRAGQJXBLMUEL-UHFFFAOYSA-N |
TGX-221 is a potent, selective, and cell-permeable PI3K p110β inhibitor with an IC50 of, demonstrating approximately 1000-fold selectivity over PI3K p110α. By targeting PI3K p110β within the PI3K/AKT signaling pathway, TGX-221 disrupts shear stress-induced phosphatidylinositol (3,4)-bisphosphate production and integrin αIIbβ3-mediated platelet adhesion. This targeted inhibition effectively impairs arterial thrombus formation, highlighting its application in cardiovascular signaling research. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12 mg/mL
(32.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
50 mg/mL
(137.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
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- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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