CAS No. 40828-46-4

Batch: Purity:99.60
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Suprofen Chemical Structure
Chemical Structure
Check the Suprofen product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid
CAS Number 40828-46-4
Molecular Formula

C14H12O3S
Molecular Weight (MW) 260.31
SMILES CC(C1=CC=C(C=C1)C(=O)C2=CC=CS2)C(=O)O
InChIKey MDKGKXOCJGEUJW-UHFFFAOYSA-N

Biological Activity

Suprofen is a non-steroidal anti-inflammatory drug (NSAID) that functions as a dual cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitor. By inhibiting COX enzymatic activity, Suprofen blocks the biosynthesis of prostaglandins from arachidonic acid. This inhibition suppresses downstream prostaglandin-mediated inflammatory signaling pathways, leading to anti-inflammatory and antipyretic cellular responses while effectively preventing intraoperative miosis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 52 mg/mL (199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 52 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Breast Cancer Res Tr. 1983;3(2):249-249.

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Note: Technical data last updated: Sep 1, 2026.