CAS No. 651-06-9
| IUPAC Name | 4-amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide | |
|---|---|---|
| CAS Number | 651-06-9 | |
| Molecular Formula |
C11H12N4O3S |
|
| Molecular Weight (MW) | 280.3 | |
| SMILES | COC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N | |
| InChIKey | GPTONYMQFTZPKC-UHFFFAOYSA-N |
Sulfameter is a long-acting sulfonamide antibacterial agent that functions as an inhibitor of dihydropteroate synthase (DHPS). By competing with para-aminobenzoic acid in the bacterial folate biosynthesis pathway, it disrupts the synthesis of folic acid required for nucleic acid production. This blockade suppresses bacterial proliferation and nucleic acid assembly, supporting its utility in research on bacterial folate metabolism and urinary tract infections.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
56 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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