CAS No. 21736-83-4
| IUPAC Name | (1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.03,8]tetradecan-7-one;dihydrochloride | |
|---|---|---|
| CAS Number | 21736-83-4 | |
| Molecular Formula |
C14H24N2O7.2HCl |
|
| Molecular Weight (MW) | 405.27 | |
| SMILES | CC1CC(=O)C2(C(O1)OC3C(C(C(C(C3O2)NC)O)NC)O)O.Cl.Cl | |
| InChIKey | FOGDPGQSHLLYIK-XYQGXRRISA-N |
Spectinomycin 2HCl is an aminocyclitol antibiotic structurally related to aminoglycosides that targets the bacterial 30S ribosomal subunit. By binding specifically to 16S ribosomal RNA, it inhibits peptidyl-tRNA translocation during protein synthesis, thereby disrupting bacterial protein translation. This mechanism results in broad antibacterial activity against various Gram-positive and Gram-negative bacteria, displaying high effectiveness against Neisseria gonorrhoeae. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(199.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 81 mg/mL |
| Ethanol | Insoluble |
| DMSO |
81 mg/mL
(199.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 81 mg/mL |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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