CAS No. 959-24-0
Batch:
Purity:99.94
Chemical Structure
Check the
Sotalol HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide;hydrochloride | |
|---|---|---|
| CAS Number | 959-24-0 | |
| Molecular Formula |
C12H20N2O3S.HCl |
|
| Molecular Weight (MW) | 308.82 | |
| SMILES | CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl | |
| InChIKey | VIDRYROWYFWGSY-UHFFFAOYSA-N |
Sotalol is a non-selective beta-adrenergic receptor antagonist and potassium channel blocker that targets cardiac potassium currents. By inhibiting cardiac potassium channels and blocking beta-adrenergic receptor activation, sotalol suppresses sympathetic stimulation and prolongs the cardiac action potential duration and effective refractory period. Downstream, these cellular electrophysiological changes attenuate abnormal automaticity and re-entrant circuits, leading to antiarrhythmic phenotypes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(200.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 62 mg/mL |
| Ethanol | Insoluble |
| DMSO |
62 mg/mL
(200.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 62 mg/mL |
| Ethanol | Insoluble |
| DMSO |
61 mg/mL
(197.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 61 mg/mL |
| Ethanol | Insoluble |
| DMSO |
61 mg/mL
(197.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 61 mg/mL |
| Ethanol | Insoluble |
| DMSO |
62 mg/mL
(200.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 62 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.