CAS No. 106308-44-5
Batch:
Purity:99.98
Chemical Structure
Check the
Rufinamide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide | |
|---|---|---|
| CAS Number | 106308-44-5 | |
| Molecular Formula |
C10H8F2N4O |
|
| Molecular Weight (MW) | 238.19 | |
| SMILES | C1=CC(=C(C(=C1)F)CN2C=C(N=N2)C(=O)N)F | |
| InChIKey | POGQSBRIGCQNEG-UHFFFAOYSA-N |
Rufinamide is a triazole derivative that functions as a voltage-gated sodium channel inhibitor. It acts predominantly by stabilizing the inactive state of voltage-gated sodium channels, thereby limiting high-frequency repetitive firing of action potentials in neurons. This suppression of sodium channel activity inhibits excessive neuronal hyperexcitability and attenuates sustained burst firing without impairing normal basal neuronal signaling. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
47 mg/mL
(197.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
18 mg/mL
(75.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
48 mg/mL
(201.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.