CAS No. 80214-83-1

Batch: Purity:99.00
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Roxithromycin Chemical Structure
Chemical Structure
Check the Roxithromycin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one
CAS Number 80214-83-1
Molecular Formula

C41H76N2O15
Molecular Weight (MW) 837.06727
SMILES CCC1C(C(C(C(=NOCOCCOC)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O
InChIKey RXZBMPWDPOLZGW-XMRMVWPWSA-N

Biological Activity

Roxithromycin is a semi-synthetic macrolide antibiotic that targets the 50S subunit of the bacterial ribosome. By binding to the 50S ribosomal subunit, it inhibits peptide translocation and disrupts bacterial protein synthesis, thereby suppressing bacterial growth. Roxithromycin displays a broad-spectrum antibacterial activity profile similar to erythromycin, showing enhanced potency against specific gram-negative organisms, particularly Legionella pneumophila. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 167 mg/mL (199.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 167 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Young RA, et al. Drugs. 1989;37(1):8-41.

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Note: Technical data last updated: Sep 1, 2026.