CAS No. 74150-27-9
Batch:
Purity:99.92
Chemical Structure
Check the
Pimobendan
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one | |
|---|---|---|
| CAS Number | 74150-27-9 | |
| Molecular Formula |
C19H18N4O2 |
|
| Molecular Weight (MW) | 334.37 | |
| SMILES | CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC | |
| InChIKey | GLBJJMFZWDBELO-UHFFFAOYSA-N |
Pimobendan is a selective phosphodiesterase 3 (PDE3) inhibitor and calcium sensitizer. It decreases carbachol-induced catecholamine secretion with an IC50 of 29.5 μM in bovine adrenal medullary cells. Furthermore, pimobendan inhibits carbachol-induced influx of Na+ (IC50 = 25.9 μM) and Ca2+ (IC50 = 26.0 μM) without suppressing veratridine- or high K+-stimulated ion fluxes, thereby modulating intracellular sodium and calcium signaling pathways. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(200.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.