CAS No. 52-67-5
Batch:
Purity:100
Chemical Structure
Check the
Penicillamine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 52-67-5 | |
|---|---|---|
| Molecular Formula |
C5H11NO2S |
|
| Molecular Weight (MW) | 149.21 | |
| SMILES | CC(C)(C(C(=O)O)N)S |
Biological Activity
Penicillamine is an orally active heavy metal chelating agent and antirheumatic drug. It forms stable chelates with metals to facilitate copper excretion in Wilson's disease and reduces excess cystine excretion in cystinuria. Penicillamine selectively depresses T-cell lymphocyte activity in vitro without affecting B-cell function and markedly lowers serum IgM rheumatoid factor levels to suppress rheumatoid arthritis disease activity. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 30 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.