CAS No. 257933-82-7

Batch: Purity:99.28
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Pelitinib (EKB-569) Chemical Structure
Chemical Structure
Check the Pelitinib (EKB-569) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide
CAS Number 257933-82-7
Molecular Formula

C24H23ClFN5O2
Molecular Weight (MW) 467.92
SMILES CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)C=CCN(C)C
InChIKey WVUNYSQLFKLYNI-AATRIKPKSA-N

Biological Activity

Pelitinib (EKB-569) is a potent, irreversible EGFR tyrosine kinase inhibitor that also inhibits Src and ErbB2 signaling. It covalently binds to epidermal growth factor receptors, blocking EGFR autophosphorylation and downstream pathway activation. By suppressing receptor phosphorylation, pelitinib inhibits tumor cell proliferation, attenuates downstream survival signaling, and induces apoptosis in EGFR-overexpressing cancer models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 13 mg/mL (27.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Wissner A, et al. J Med Chem. 2003;46(1):49-63.

[2] Torrance CJ, et al. Nat Med. 2000;6(9):1024-8.

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Note: Technical data last updated: Sep 1, 2026.