Clinical Trials

Pazopanib HCl has been evaluated across numerous clinical trials spanning Early Phase 1 through Phase 4, with research predominantly focusing on oncologic and vascular conditions such as soft-tissue sarcoma, renal cell carcinoma, non-small cell lung cancer, breast cancer, and hereditary hemorrhagic telangiectasia. These investigations include both completed and actively recruiting protocols supported by academic, governmental, non-profit, and pharmaceutical sponsors.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06239272 RECRUITING
Adipocytic Neoplasm; Liposarcoma; Atypical Fibroxanthoma; Angiomatoid Fibrous Histiocytoma; Fibrosarcoma NOS; Myxofibrosarcoma; Angiosarcoma; Osteosarcoma, Extraskeletal; Dedifferentiated Liposarcoma; Myxoid Liposarcoma; Pleomorphic Liposarcoma; Myxoid Pleomorphic Liposarcoma; Low Grade Fibromyxoid Sarcoma; Sclerosing Epithelioid Fibrosarcoma; Malignant Tenosynovial Giant Cell Tumor of Soft Tissue; Epithelioid Hemangioendothelioma; Glomus Tumor; Inflammatory Leiomyosarcoma; Leiomyosarcoma; Ossifying Fibromyxoid Tumor, Malignant; Myoepithelioma; Synovial Sarcoma; Epithelioid Sarcoma; Perineurioma, Malignant; Clear Cell Sarcoma; Extraskeletal Myxoid Chondrosarcoma; Granular Cell Tumor, Malignant; Melanotic Malignant Nerve Sheath Tumor; Malignant Peripheral Nerve Sheath Tumor; Perivascular Epithelioid Tumor, Malignant; Intimal Sarcoma; Myoepithelial Carcinoma; Undifferentiated Sarcoma; Pleomorphic Sarcoma, Undifferentiated; Round Cell Sarcoma, Undifferentiated; NTRK-Rearranged Spindle Cell Neoplasm; Phosphaturic Mesenchymal Tumor, Malignant; Round Cell Sarcoma; Well Differentiated Liposarcoma; Giant Cell Tumor of Soft Parts NOS; Low Grade Myofibroblastic Sarcoma; Dermatofibrosarcoma Protuberans, Fibrosarcomatous
St. Jude Children's Research Hospital
 2024-03-27 PHASE1; PHASE2
NCT07444619 RECRUITING
Soft Tissue Sarcomas
M.D. Anderson Cancer Center
 2026-06-12 PHASE1
NCT06726421 RECRUITING
Renal Cell Carcinoma (Kidney Cancer); Kidney Cancer Metastatic; Renal Cell Carcinoma Metastatic
Sun Yat-sen University
 2024-09-18 PHASE3
NCT04199026 RECRUITING
Metastatic Sarcoma; Recurrent Sarcoma; Resectable Sarcoma
M.D. Anderson Cancer Center
 2025-02-25
NCT01217931 ACTIVE_NOT_RECRUITING
Kidney Cancer
M.D. Anderson Cancer Center
 2011-01-19 PHASE2
NCT02029001 RECRUITING
Malignant Solid Neoplasms
Centre Leon Berard
 2014-03 PHASE2
NCT06263231 RECRUITING
Sarcoma,Soft Tissue
Intensity Therapeutics, Inc.
 2024-06-28 PHASE3
NCT02331498 ACTIVE_NOT_RECRUITING
Glioblastoma Multiforme
Centre Antoine Lacassagne
 2015-06 PHASE1; PHASE2
NCT05180695 ACTIVE_NOT_RECRUITING
Advanced Soft-tissue Sarcoma; Metastatic Soft-tissue Sarcoma
Centre Leon Berard
 2022-04-15 PHASE1; PHASE2
NCT05679921 RECRUITING
Soft Tissue Sarcoma
Yonsei University
 2024-03-01 PHASE2
NCT06739395 RECRUITING
Solid Tumor; Precision Medicine
Tianjin Medical University Second Hospital
 2024-11-01 PHASE2
NCT07087158 RECRUITING
Renal Cell Carcinoma (RCC)
Imbioray (Hangzhou) Biomedicine Co., Ltd.
 2025-09-08 PHASE2
NCT03592472 RECRUITING
Renal Cell Carcinoma
Xynomic Pharmaceuticals, Inc.
 2018-07-17 PHASE3
NCT01684397 ACTIVE_NOT_RECRUITING
Clear Cell Renal Cell Carcinoma; Stage IV Renal Cell Cancer
Roswell Park Cancer Institute
 2012-11-21 PHASE1; PHASE2
NCT06816771 RECRUITING
Rhabdomyosarcoma, Recurrent, Refractory
Shandong Cancer Hospital and Institute
 2025-02 PHASE2
NCT06895733 RECRUITING
Solid Tumor, Adult; Next-generation Sequencing; Precision Medicine
Tianjin Medical University Second Hospital
 2024-11-27 PHASE1; PHASE2
NCT03850964 ACTIVE_NOT_RECRUITING
Hereditary Hemorrhagic Telangiectasia; Epistaxis; Anemia; Nosebleed; HHT
Cure HHT
 2023-05-08 PHASE2; PHASE3
NCT05210413 ACTIVE_NOT_RECRUITING
Refractory or Recurrent Solid Tumor
University Hospital, Bordeaux
 2022-05-17 PHASE1; PHASE2
NCT03850730 UNKNOWN
Hereditary Hemorrhagic Telangiectasia; Epistaxis
Cure HHT
 2023-07-01 PHASE1; PHASE2
NCT05949424 UNKNOWN
Renal Cell Carcinoma; Ovarian Carcinoma; Thyroid Carcinoma; Breast Carcinoma; Endometrium Carcinoma
University Medical Center Groningen
 2024-05 PHASE4
NCT04741438 UNKNOWN
Sarcoma
Centre Leon Berard
 2021-03-30 PHASE3
NCT02203760 ACTIVE_NOT_RECRUITING
Leiomyosarcoma or Carcinosarcoma
North Eastern German Society of Gynaecological Oncology
 2019-10-16 PHASE2
NCT05432791 ACTIVE_NOT_RECRUITING
Locally Advanced Uterine Corpus Leiomyosarcoma; Metastatic Uterine Corpus Leiomyosarcoma; Stage III Uterine Corpus Leiomyosarcoma AJCC v8; Stage IV Uterine Corpus Leiomyosarcoma AJCC v8; Unresectable Uterine Corpus Leiomyosarcoma
National Cancer Institute (NCI)
 2023-03-30 PHASE2; PHASE3
NCT01436227 COMPLETED
Von Hippel-Lindau Syndrome
M.D. Anderson Cancer Center
 2012-01-17 PHASE2
NCT01543763 COMPLETED
Metastatic Solid Tumors
Pamela Munster
 2012-06-25 PHASE1
NCT05816642 UNKNOWN
Metastatic Renal Cell Carcinoma
RenJi Hospital
 2022-08-01
NCT03628131 UNKNOWN
Relapsed Pediatric Solid Tumor; Refractory Pediatric Solid Tumor
Samsung Medical Center
 2018-10 PHASE1; PHASE2
NCT03850964 Recruiting
Hereditary Hemorrhagic Telangiectasia|Epistaxis|Anemia|Nosebleed|HHT
Cure HHT
 2023-05-08 Phase 2|Phase 3
NCT03660930 TERMINATED
Advanced Soft Tissue Sarcoma; Locally Advanced Soft Tissue Sarcoma; Metastatic Soft Tissue Sarcoma
University of Washington
 2019-04-01 PHASE1; PHASE2
NCT03571438 UNKNOWN
Kidney Cancer
University Hospital, Grenoble
 2017-10-16
NCT03798106 COMPLETED
Sarcoma
Yonsei University
 2019-04-10 PHASE2
NCT02303028 COMPLETED
Solid Tumors
The Hospital for Sick Children
 2015-03 PHASE1; PHASE2
NCT05180695 Recruiting
Advanced Soft-tissue Sarcoma|Metastatic Soft-tissue Sarcoma
Centre Leon Berard|Novartis|National Cancer Institute France
 2022-04-15 Phase 1|Phase 2
NCT02638428 UNKNOWN
Relapsed Pediatric Solid Tumor; Refractory Pediatric Solid Tumor; Relapsed Pediatric AML; Refractory Pediatric AML
Samsung Medical Center
 2015-12 PHASE2
NCT01548144 TERMINATED
Advanced Cancers
M.D. Anderson Cancer Center
 2012-04 PHASE1
NCT03200717 COMPLETED
Advanced Renal Cell Carcinoma; Metastatic Renal Cell Carcinoma
Novartis Pharmaceuticals
 2017-11-14 PHASE2
NCT03334409 TERMINATED
Clear Cell Renal Cell Carcinoma; Metastatic Clear Cell Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v7; Unresectable Renal Cell Carcinoma
Academic and Community Cancer Research United
 2018-02-16 PHASE2
NCT02960906 COMPLETED
Clear Cell Metastatic Renal Cell Carcinoma
Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie
 2017-05-31 PHASE2
NCT01664182 COMPLETED
Advanced Renal Cell Carcinoma; Advanced Sarcomatoid Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v7; Stage IV Renal Cell Cancer AJCC v7
National Cancer Institute (NCI)
 2012-08-01 PHASE2
NCT03735758 TERMINATED
Soft Tissue Sarcoma Adult
GWT-TUD GmbH
 2018-11-02 PHASE4
NCT02959554 TERMINATED
Metastatic Renal Cell Carcinoma
AIO-Studien-gGmbH
 2016-12 PHASE2
NCT01430572 COMPLETED
Advanced Cancers; Solid Tumors
M.D. Anderson Cancer Center
 2011-10-07 PHASE1
NCT01566747 COMPLETED
Renal Cell Carcinoma
Cancer Trials Ireland
 2011-03 PHASE2
NCT01236547 COMPLETED
Thyroid Gland Anaplastic Carcinoma
National Cancer Institute (NCI)
 2010-10-28 PHASE2
NCT02555748 COMPLETED
Metastatic Renal Cell Cancer
Institut Claudius Regaud
 2015-11-17 PHASE4
NCT02342600 WITHDRAWN
Gastrointestinal Stromal Tumors
Sarcoma Alliance for Research through Collaboration
 2017-01 PHASE2
NCT02212015 TERMINATED
Angiosarcoma
Heidelberg University
 2014-07 PHASE2
NCT02193152 TERMINATED
Carcinoma, Non-Small Cell Lung; Non-Small Cell Lung Cancer; Nonsmall Cell Lung Cancer
Washington University School of Medicine
 2015-04-27 PHASE2
NCT02066285 COMPLETED
Solitary Fibrous Tumor; Extraskeletal Myxoid Chondrosarcoma
Grupo Espanol de Investigacion en Sarcomas
 2014-06 PHASE2
NCT01956669 COMPLETED
Solid Tumours
Novartis Pharmaceuticals
 2014-10-08 PHASE2
NCT01532687 COMPLETED
Adult Alveolar Soft Part Sarcoma; Adult Angiosarcoma; Adult Desmoplastic Small Round Cell Tumor; Adult Epithelioid Hemangioendothelioma; Adult Epithelioid Sarcoma; Adult Extraskeletal Myxoid Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Peripheral Nerve Sheath Tumor; Adult Rhabdomyosarcoma; Adult Synovial Sarcoma; Adult Undifferentiated Pleomorphic Sarcoma; Malignant Adult Hemangiopericytoma; Recurrent Adult Soft Tissue Sarcoma; Sarcoma; Stage III Adult Soft Tissue Sarcoma AJCC v7; Stage IV Adult Soft Tissue Sarcoma AJCC v7
OHSU Knight Cancer Institute
 2012-03-13 PHASE2
NCT03139331 COMPLETED
Sarcoma; Refractory Sarcoma
University of California, San Francisco
 2017-06-06 PHASE1
NCT01931098 COMPLETED
Glioblastoma; Glioblastoma Multiforme; Gliosarcoma; Brain Neoplasms; Central Nervous System Neoplasms
National Cancer Institute (NCI)
 2015-12-10 PHASE2
NCT01392183 COMPLETED
Kidney Cancer
M.D. Anderson Cancer Center
 2012-10-24 PHASE2
NCT02383251 COMPLETED
Ovarian Cancer
ARCAGY/ GINECO GROUP
 2015-06-15 PHASE2
NCT02348398 WITHDRAWN
Cervical Cancer
M.D. Anderson Cancer Center
 2016-08 PHASE2
NCT02180867 COMPLETED
Alveolar Soft Part Sarcoma; Angiomatoid Fibrous Histiocytoma; Atypical Fibroxanthoma; Clear Cell Sarcoma of Soft Tissue; Epithelioid Malignant Peripheral Nerve Sheath Tumor; Epithelioid Sarcoma; Extraskeletal Myxoid Chondrosarcoma; Extraskeletal Osteosarcoma; Fibrohistiocytic Neoplasm; Fibrosarcoma; Inflammatory Myofibroblastic Tumor; Intimal Sarcoma; Leiomyosarcoma; Liposarcoma; Liver Embryonal Sarcoma; Low Grade Fibromyxoid Sarcoma; Low Grade Myofibroblastic Sarcoma; Malignant Peripheral Nerve Sheath Tumor; Malignant Skin Granular Cell Tumor; Malignant Triton Tumor; Mesenchymal Chondrosarcoma; Myxofibrosarcoma; Myxoid Chondrosarcoma; Myxoinflammatory Fibroblastic Sarcoma; Nerve Sheath Neoplasm; PEComa; Pericytic Neoplasm; Plexiform Fibrohistiocytic Tumor; Sclerosing Epithelioid Fibrosarcoma; Skin Glomus Tumor; Stage IB Soft Tissue Sarcoma AJCC v7; Stage IIB Soft Tissue Sarcoma AJCC v7; Stage III Soft Tissue Sarcoma AJCC v7; Stage IV Soft Tissue Sarcoma AJCC v7; Synovial Sarcoma; Undifferentiated High Grade Pleomorphic Sarcoma of Bone
National Cancer Institute (NCI)
 2014-08-12 PHASE2; PHASE3
NCT02300545 COMPLETED
Sarcoma, Soft Tissue; Soft Tissue Sarcoma
Washington University School of Medicine
 2015-04-08 PHASE2
NCT01402271 COMPLETED
Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
European Organisation for Research and Treatment of Cancer - EORTC
 2012-07 PHASE1; PHASE2
NCT01593748 COMPLETED
Sarcoma
Medical University of South Carolina
 2012-09-27 PHASE2
NCT02979899 COMPLETED
Advanced Angiosarcoma
Tracon Pharmaceuticals Inc.
 2017-02-13 PHASE3
NCT02575066 TERMINATED
Sarcoma; Soft Tissue Sarcomas
The Netherlands Cancer Institute
 2016-03-17 PHASE2
NCT01975519 COMPLETED
Advanced Soft Tissue Sarcoma
Tracon Pharmaceuticals Inc.
 2013-12-10 PHASE1; PHASE2
NCT01841736 ACTIVE_NOT_RECRUITING
Foregut Neuroendocrine Tumor; Hindgut Neuroendocrine Tumor; Metastatic Digestive System Neuroendocrine Tumor G1; Metastatic Neuroendocrine Tumor; Midgut Neuroendocrine Tumor G1; Neuroendocrine Tumor G2; Recurrent Digestive System Neuroendocrine Tumor G1; Regional Digestive System Neuroendocrine Tumor G1
National Cancer Institute (NCI)
 2013-09-20 PHASE2
NCT02014636 COMPLETED
Carcinoma, Renal Cell
Novartis Pharmaceuticals
 2013-12-27 PHASE1
NCT02009449 COMPLETED
Melanoma; Prostate Cancer; Ovarian Cancer; Renal Cell Carcinoma; Colorectal Carcinoma; Pancreatic Carcinoma; Non-small Cell Lung Carcinoma; Solid Tumors; Breast Cancer
Eli Lilly and Company
 2013-11-15 PHASE1
NCT01767636 COMPLETED
Carcinoma of the Collecting Ducts of Bellini; Chromophobe Renal Cell Carcinoma; Kidney Medullary Carcinoma; Kidney Oncocytoma; Metastatic Renal Cell Cancer; Papillary Renal Cell Carcinoma; Recurrent Renal Cell Carcinoma; Sarcomatoid Renal Cell Carcinoma; Stage IV Renal Cell Cancer
Mayo Clinic
 2013-05-16 PHASE2
NCT01462630 COMPLETED
Adult Angiosarcoma; Recurrent Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma
Fox Chase Cancer Center
 2011-11-03 PHASE2
NCT01446809 COMPLETED
Stage IIA Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma
University of Washington
 2012-04
NCT01813136 COMPLETED
Thyroid Carcinoma
Centre Leon Berard
 2013-03 PHASE2
NCT00625846 COMPLETED
Recurrent Thyroid Gland Carcinoma; Stage III Differentiated Thyroid Gland Carcinoma AJCC v7; Stage III Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVA Differentiated Thyroid Gland Carcinoma AJCC v7; Stage IVA Thyroid Gland Anaplastic Carcinoma AJCC v7; Stage IVA Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVB Differentiated Thyroid Gland Carcinoma AJCC v7; Stage IVB Thyroid Gland Anaplastic Carcinoma AJCC v7; Stage IVB Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVC Differentiated Thyroid Gland Carcinoma AJCC v7; Stage IVC Thyroid Gland Anaplastic Carcinoma AJCC v7; Stage IVC Thyroid Gland Medullary Carcinoma AJCC v7; Thyroid Gland Anaplastic Carcinoma
National Cancer Institute (NCI)
 2008-02-22 PHASE2
NCT02601209 TERMINATED
High Grade Sarcoma; Metastatic Leiomyosarcoma; Metastatic Malignant Peripheral Nerve Sheath Tumor; Metastatic Synovial Sarcoma; Metastatic Undifferentiated Pleomorphic Sarcoma; Metastatic Unresectable Sarcoma; Myxofibrosarcoma; Recurrent Leiomyosarcoma; Recurrent Malignant Peripheral Nerve Sheath Tumor; Recurrent Synovial Sarcoma; Recurrent Undifferentiated Pleomorphic Sarcoma; Stage III Uterine Corpus Leiomyosarcoma AJCC v8; Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8; Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8; Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8; Stage IV Uterine Corpus Leiomyosarcoma AJCC v8; Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8; Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8; Unresectable Leiomyosarcoma
National Cancer Institute (NCI)
 2015-11-30 PHASE1; PHASE2
NCT02570789 TERMINATED
Clear-cell Metastatic Renal Cell Carcinoma
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
 2012-12 PHASE4
NCT03735758 Terminated
Soft Tissue Sarcoma Adult
GWT-TUD GmbH
 2018-11-02 Phase 4
NCT02138526 COMPLETED
Cancer
Radboud University Medical Center
 2014-06 PHASE1
NCT02535351 TERMINATED
Clear-cell Metastatic Renal Cell Carcinoma
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
 2015-11 PHASE3
NCT01855724 TERMINATED
Cholangiocarcinoma; Gallbladder Carcinoma; Biliary Carcinoma
Hellenic Cooperative Oncology Group
 2013-06-28 PHASE2
NCT03260894 COMPLETED
Renal Cell Carcinoma (RCC)
Incyte Corporation
 2017-12-07 PHASE3
NCT01465659 COMPLETED
Pancreatic Alpha Cell Carcinoma; Pancreatic Beta Islet Cell Carcinoma; Pancreatic Delta Cell Carcinoma; Pancreatic G-cell Carcinoma; Recurrent Islet Cell Carcinoma
Northwestern University
 2011-12-12 PHASE1; PHASE2
NCT01575548 ACTIVE_NOT_RECRUITING
Clear Cell Renal Cell Carcinoma; Stage IV Renal Cell Cancer AJCC v7
National Cancer Institute (NCI)
 2012-08-08 PHASE3
NCT03275558 WITHDRAWN
Recurrent Glioblastoma; Gliosarcoma; Anaplastic Gliomas
Center Trials & Treatment
 2018-07-17 PHASE1
NCT01610206 COMPLETED
Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer
Linda R Duska
 2012-09 PHASE2
NCT02367651 WITHDRAWN
Sarcoma, Soft Tissue
GlaxoSmithKline
 2015-06 PHASE2
NCT02357810 COMPLETED
Adult Liposarcoma; Metastatic Liposarcoma; Metastatic Osteosarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Liposarcoma; Recurrent Osteosarcoma; Stage IV Adult Soft Tissue Sarcoma
Northwestern University
 2015-03-21 PHASE2
NCT01876082 COMPLETED
Progressive Desmoids Tumors
Institut Bergonié
 2012-09-18 PHASE2
NCT01692496 COMPLETED
Advanced and / or Metastatic Liposarcoma
Grupo Espanol de Investigacion en Sarcomas
 2013-01-29 PHASE2
NCT01442662 COMPLETED
Leiomyosarcoma
UNICANCER
 2011-09 PHASE2
NCT01107665 COMPLETED
Stage III Melanoma; Stage IV Melanoma; Unresectable Melanoma
University of California, Irvine
 2010-08 PHASE2
NCT02208128 UNKNOWN
Renal Cell Carcinoma
Heidelberg University
 2014-05
NCT01330966 COMPLETED
Chondrosarcoma; Metastatic Chondrosarcoma
Emerald Clinical Inc.
 2011-04 PHASE2
NCT03379012 COMPLETED
Metastatic Renal Cell Carcinoma
Kidney Cancer Research Bureau
 2016-02-08 PHASE2
NCT01468909 COMPLETED
Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma
National Cancer Institute (NCI)
 2011-12-12 PHASE2
NCT02691767 COMPLETED
Refractory Solid Tumors
Samsung Medical Center
 2016-05
NCT01636908 COMPLETED
Cancer; Advanced Solid Tumors
Amsterdam UMC, location VUmc
 2011-08
NCT02378142 WITHDRAWN
Uterine Leiomyosarcoma
Gynecologic Oncology Group
 2015-03 PHASE2
NCT01503372 COMPLETED
Advanced Gastric Cancer
Charite University, Berlin, Germany
 2011-11 PHASE2
NCT02406521 COMPLETED
Metastatic Renal Cell Carcinoma
Dana-Farber Cancer Institute
 2015-04 PHASE1
NCT02055690 TERMINATED
Ovarian Neoplasms; Neoplasms, Ovarian; Ovarian Cancer
The Christie NHS Foundation Trust
 2014-09 PHASE1; PHASE2
NCT02122003 TERMINATED
Metastatic Renal Cell Carcinoma
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
 2016-09 PHASE2
NCT01642017 TERMINATED
Metastatic Cancer (Different Solid Tumour Types)
Institut Claudius Regaud
 2012-11-22 PHASE1
NCT02729194 COMPLETED
Carcinoma, Renal Cell
University of Michigan Rogel Cancer Center
 2016-06 EARLY_PHASE1
NCT02810756 COMPLETED
Pharmacokinetics of Pazopanib
The Netherlands Cancer Institute
 2016-09-15 EARLY_PHASE1
NCT03149120 WITHDRAWN
Soft Tissue Sarcomas
NYU Langone Health
 2017-08 PHASE2
NCT02450136 COMPLETED
Refractory Solid Tumors
Samsung Medical Center
 2015-10-08
NCT02560012 TERMINATED
Carcinoma, Renal Cell
The University of Texas Health Science Center, Houston
 2016-01-04 PHASE2
NCT01861951 COMPLETED
Soft Tissue Sarcoma
Hannover Medical School
 2012-10 PHASE2
NCT01521715 COMPLETED
Locally Advanced and/or Metastatic Renal Cell Carcinoma; Carcinoma, Renal Cell; Clear-cell Metastatic Renal Cell Carcinoma
iOMEDICO AG
 2012-01-24 PHASE4
NCT01339871 COMPLETED
Advanced Cancer
M.D. Anderson Cancer Center
 2011-04-20 PHASE1
NCT02049905 COMPLETED
Metastatic, Locally Advanced or Unresectable Soft Tissue Sarcoma
ImmunityBio, Inc.
 2014-01 PHASE3
NCT01600573 UNKNOWN
Ovarian Cancer
JSehouli
 2012-05 PHASE1; PHASE2
NCT01184326 COMPLETED
Solid Tumor; Kidney Cancer
Dana-Farber Cancer Institute
 2011-01 PHASE1
NCT04462445 COMPLETED
Metastatic Renal Cell Carcinoma
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
 2015-06-25 PHASE2
NCT01832259 COMPLETED
Adenocarcinoma of the Prostate
University of Utah
 2013-08 PHASE2
NCT01797874 COMPLETED
SCLC
Samsung Medical Center
 2013-06 PHASE2
NCT01759303 TERMINATED
Osteosarcoma; Metastatic Osteosarcoma
Emerald Clinical Inc.
 2013-04 PHASE2
NCT02795819 TERMINATED
Renal Cell Carcinoma; Soft Tissue Sarcoma; Metastatic Disease
Virginia Commonwealth University
 2016-07-08 PHASE1
NCT01545817 TERMINATED
Carcinoma, Renal Cell
Novartis Pharmaceuticals
 2012-04-19 PHASE2
NCT01613846 COMPLETED
Renal Cell Carcinoma
Technical University of Munich
 2012-05 PHASE3
NCT01543802 TERMINATED
Sarcoma, Soft-tissue
Heidelberg University
 2013-04 PHASE2
NCT02279576 TERMINATED
Penile Squamous Cell Carcinoma Stage IV
Spanish Oncology Genito-Urinary Group
 2015-01 PHASE2
NCT02113826 TERMINATED
Metastatic Alveolar Soft Part Sarcoma
Seoul National University Hospital
 2014-04 PHASE2
NCT01713972 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
Manisha Shah
 2012-11-19 PHASE1
NCT02207309 TERMINATED
Sarcoma
Ludwig-Maximilians - University of Munich
 2015-06-22 PHASE2
NCT01639911 COMPLETED
Malignant Neoplasm of Breast; CNS Malignancy; Malignant Neoplasm of Gastrointestinal Tract; Genitourinary Neoplasms Malignancy and Gender Unspecified; Head and Neck Neoplasms; Melanoma; Malignant Neoplasm of Thorax
University of Illinois at Chicago
 2013-08-14 PHASE1
NCT01743482 COMPLETED
Germ Cell Tumors; Measurable Disease
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
 2013-05-17 PHASE2
NCT01514448 COMPLETED
Metastatic Renal Cell Carcinoma (mRCC)
Novartis Pharmaceuticals
 2012-05-21 PHASE4
NCT01438554 COMPLETED
Solid Tumors; Thyroid Cancer; Soft-tissue Sarcoma; Cholangiocarcinoma
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2011-10 PHASE1
NCT01961583 TERMINATED
Kidney Neoplasm
Asan Medical Center
 2013-09 PHASE2
NCT01407562 TERMINATED
Unspecified Adult Solid Tumor - Protocol Specific; Breast Cancer - Female
Rutgers, The State University of New Jersey
 2010-09-17 PHASE1
NCT02089802 TERMINATED
Locally Advanced Renal Cell Carcinoma; Metastatic Renal Cell Carcinoma
Interessenverband zur Qualitätssicherung der Arbeit niedergelassener Uro-Onkologen in Deutschland e.
 2014-02-25 PHASE2
NCT01361334 COMPLETED
Acute Myeloid Leukemia
University Hospital Muenster
 2011-06 PHASE2
NCT02204371 TERMINATED
Telangiectasia, Hereditary Hemorrhagic
GlaxoSmithKline
 2015-02-25 PHASE2
NCT01472081 COMPLETED
Renal Cell Carcinoma; Clear-cell Metastatic Renal Cell Carcinoma
Bristol-Myers Squibb
 2012-02-09 PHASE1
NCT01622660 TERMINATED
Bladder Cancer
Memorial Sloan Kettering Cancer Center
 2012-06 PHASE2
NCT01247571 COMPLETED
Recurrent Uterine Corpus Sarcoma; Uterine Carcinosarcoma
National Cancer Institute (NCI)
 2011-01 PHASE2
NCT01158521 COMPLETED
Clear Cell Renal Cell Carcinoma; Stage I Renal Cell Cancer; Stage II Renal Cell Cancer; Stage III Renal Cell Cancer
Case Comprehensive Cancer Center
 2010-06 PHASE2
NCT02393820 COMPLETED
Salivary Gland Carcinoma
UNICANCER
 2013-08-26 PHASE2
NCT01552356 ACTIVE_NOT_RECRUITING
Solid Neoplasm
National Cancer Institute (NCI)
 2012-03-19 PHASE1
NCT01466972 COMPLETED
Breast Cancer; Breast Neoplasm
Hope Rugo, MD
 2012-04-27 PHASE2
NCT01599832 TERMINATED
Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Cancer; Stage IV Renal Cell Cancer
University of Chicago
 2012-06
NCT02324803 UNKNOWN
Self Efficacy; Adverse Drug Event; Carcinoma, Renal Cell
Southern China Urology Cancer Consortium
 2014-07 PHASE2
NCT01513187 COMPLETED
Advanced Renal Cell Carcinoma
Spanish Oncology Genito-Urinary Group
 2011-07-11 PHASE1; PHASE2
NCT00775307 COMPLETED
Carcinoma, Non-Small-Cell Lung
Intergroupe Francophone de Cancerologie Thoracique
 2008-11 PHASE2; PHASE3
NCT01418001 TERMINATED
Sarcoma; Leiomyosarcoma; Malignant Peripheral Nerve Sheath Tumor; Malignant Fibrous; Histiocytoma/Undifferentiated Pleomorphic Sarcoma
Memorial Sloan Kettering Cancer Center
 2011-08 PHASE1; PHASE2
NCT01235962 COMPLETED
Renal Cell Carcinoma (RCC); Cancer
Novartis Pharmaceuticals
 2010-11-30 PHASE3
NCT02307474 WITHDRAWN
Clear Cell Renal Cell Carcinoma; Renal Cell Carcinoma
Case Comprehensive Cancer Center
 2015-09
NCT00486642 COMPLETED
Hormone-Resistant Prostate Cancer; Recurrent Prostate Carcinoma
National Cancer Institute (NCI)
 2007-09 PHASE2
NCT01716416 COMPLETED
Squamous Cell Carcinoma of the Head and Neck
Washington University School of Medicine
 2013-05-31 PHASE1
NCT01385228 COMPLETED
Prostate Cancer
Daniel George, MD
 2011-06 PHASE1
NCT01221506 COMPLETED
Carcinoma, Renal Cell
Abramson Cancer Center at Penn Medicine
 2010-10 EARLY_PHASE1
NCT01130805 COMPLETED
Gastric Cancer
Samsung Medical Center
 2010-12 PHASE2
NCT01208064 TERMINATED
Lung Cancer
European Organisation for Research and Treatment of Cancer - EORTC
 2011-07 PHASE2; PHASE3
NCT00800345 COMPLETED
Gynecologic Tumors
Vector Oncology
 2009-04 PHASE1
NCT01608009 COMPLETED
Ovarian Neoplasm
Imperial College London
 2012-07 PHASE1
NCT01719302 COMPLETED
Stage III Adult Soft Tissue Sarcoma
University of Vermont
 2012-10 PHASE1; PHASE2
NCT01713296 COMPLETED
SCLC
Hellenic Oncology Research Group
 2011-11 PHASE2
NCT01454804 COMPLETED
Advanced Cancers
M.D. Anderson Cancer Center
 2011-10 PHASE1
NCT01538238 COMPLETED
Locally Advanced or Metastatic Non-clear Cell Type Renal Cell Carcinoma
Samsung Medical Center
 2012-05-02 PHASE2
NCT01361113 COMPLETED
Renal Cell Carcinoma
UNC Lineberger Comprehensive Cancer Center
 2011-06 PHASE2
NCT01524848 COMPLETED
Gastrointestinal Stromal Tumors
Scandinavian Sarcoma Group
 2012-02 PHASE2
NCT01716546 TERMINATED
Gastric Cancer
Hellenic Oncology Research Group
 2011-07 PHASE1; PHASE2
NCT01108055 COMPLETED
Bladder Cancer; Bladder (Urothelial, Transitional Cell) Cancer; Bladder (Urothelial, Transitional Cell) Cancer Superficial (Non-Invasive); Bladder (Urothelial, Transitional Cell) Cancer Resectable (Pre-Cystectomy); Bladder (Urothelial, Transitional Cell) Cancer Metastatic or Unresectable
Sandy Srinivas
 2010-04 PHASE2
NCT01340794 TERMINATED
Extra-Adrenal Paraganglioma; Metastatic Adrenal Gland Pheochromocytoma; Paraganglioma; Recurrent Adrenal Gland Pheochromocytoma
National Cancer Institute (NCI)
 2011-05 PHASE2
NCT01238770 COMPLETED
Epithelial Ovarian Cancer
Priv.-Doz. Dr. med. Joachim Rom
 2010-11 PHASE1; PHASE2
NCT01577784 UNKNOWN
Metastatic Renal Cell Carcinoma
Associació per a la Recerca Oncologica, Spain
 2012-04 PHASE2
NCT01666418 COMPLETED
Melanoma
University of Zurich
 2012-08 PHASE2
NCT01506596 COMPLETED
Liposarcoma; Surgically Unresectable Liposarcoma; Metastatic Liposarcoma
Vector Oncology
 2012-03 PHASE2
NCT01468922 COMPLETED
Solid Tumor
National Cancer Institute (NCI)
 2012-01-23 PHASE1
NCT01392352 TERMINATED
Renal Cell Carcinoma; Soft Tissue Sarcoma; Glioblastoma; Ovarian Cancer; Cervical Cancer; Breast Cancer; Non-small Cell Lung Cancer; Small Cell Lung Cancer; Pancreatic Cancer; Melanoma; Gastrointestinal Cancer
Cambridge University Hospitals NHS Foundation Trust
 2011-04 PHASE2
NCT01262820 COMPLETED
Lung Cancer
UNC Lineberger Comprehensive Cancer Center
 2010-12 PHASE2
NCT01985295 COMPLETED
Sarcoma,Soft Tissue
The Netherlands Cancer Institute
 2010-06 PHASE1
NCT01644825 COMPLETED
Ovarian Cancer
National Cancer Institute, Naples
 2010-12 PHASE2
NCT01027598 COMPLETED
Non Small Cell Lung Cancer
SCRI Development Innovations, LLC
 2010-01 PHASE2
NCT01323400 COMPLETED
GIST
Centre Leon Berard
 2011-03 PHASE2
NCT01408004 COMPLETED
Clear Cell Renal Carcinoma
Netherlands Working Group on Immunotherapy of Oncology
 2011-11 PHASE2
NCT01059656 TERMINATED
Dermatofibrosarcomas of DARIER FERRAND(DFSP)
Assistance Publique - Hôpitaux de Paris
 2010-07 PHASE2
NCT00454363 COMPLETED
Gastrin-Producing Neuroendocrine Tumor; Lung Carcinoid Tumor; Metastatic Digestive System Neuroendocrine Tumor G1; Multiple Endocrine Neoplasia Type 1; Pancreatic Glucagonoma; Pancreatic Insulinoma; Pancreatic Polypeptide Tumor; Recurrent Digestive System Neuroendocrine Tumor G1; Recurrent Pancreatic Neuroendocrine Carcinoma; Regional Digestive System Neuroendocrine Tumor G1; Somatostatin-Producing Neuroendocrine Tumor
National Cancer Institute (NCI)
 2007-03 PHASE2
NCT01049776 TERMINATED
Non Small Cell Lung Cancer
Illinois CancerCare, P.C.
 2010-01 PHASE2
NCT01262014 COMPLETED
Platinum-resistant Advanced Ovarian Cancer
Grupo Español de Investigación en Cáncer de Ovario
 2010-12 PHASE2
NCT00297258 COMPLETED
Sarcoma, Soft Tissue
GlaxoSmithKline
 2005-11 PHASE2
NCT00992121 COMPLETED
Carcinoma, Renal Cell
GlaxoSmithKline
 2009-11-18 PHASE1
NCT01413113 COMPLETED
Recurrent Thyroid Cancer; Stage IVA Follicular Thyroid Cancer; Stage IVA Papillary Thyroid Cancer; Stage IVB Follicular Thyroid Cancer; Stage IVB Papillary Thyroid Cancer; Stage IVC Follicular Thyroid Cancer; Stage IVC Papillary Thyroid Cancer
University of Washington
 2011-12 PHASE1
NCT01157091 COMPLETED
Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Cancer; Stage IV Renal Cell Cancer
City of Hope Medical Center
 2010-12-08 PHASE2
NCT01165385 COMPLETED
Solid Tumors; Metastatic Cancer
UNICANCER
 2010-06 PHASE1
NCT00732420 COMPLETED
Solid Tumours
GlaxoSmithKline
 2008-09-24 PHASE1
NCT01391611 TERMINATED
Gastrointestinal Stromal Tumor (GIST)
Kristen Ganjoo
 2011-07 PHASE2
NCT01377298 UNKNOWN
Head and Neck Squamous Cell Carcinoma
National Taiwan University Hospital
 2011-06 PHASE2
NCT00929903 COMPLETED
Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Metastatic Childhood Soft Tissue Sarcoma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Central Nervous System Embryonal Tumor; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Childhood Visual Pathway Glioma; Unspecified Childhood Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2009-06 PHASE1
NCT01280201 COMPLETED
Advanced/Metastatic Neuroendocrine Tumors
Grupo Espanol de Tumores Neuroendocrinos
 2011-01-26 PHASE2
NCT00387205 COMPLETED
Carcinoma, Renal Cell
Novartis Pharmaceuticals
 2006-06-20 PHASE1
NCT01485042 COMPLETED
Solid Tumors
Herbert Hurwitz, MD
 2011-12 PHASE1
NCT01012362 TERMINATED
Breast Cancer; Lung Cancer; Colon Cancer; Pancreatic Cancer; Head and Neck Cancer; Kidney Cancer; Sarcoma; Hepatocellular Cancer
Masonic Cancer Center, University of Minnesota
 2009-12 PHASE1
NCT01542047 TERMINATED
Cancer, Metastatic
New Mexico Cancer Research Alliance
 2012-08 PHASE1
NCT00674024 COMPLETED
Neoplasms; Lymphoma
National Cancer Institute (NCI)
 2008-10-07 PHASE1
NCT01202032 COMPLETED
Metastatic Renal Cell Carcinoma; Advanced Refractory Solid Tumors Histologically or Cytologically Confirmed
Centre Leon Berard
 2010-07 PHASE1
NCT00615524 WITHDRAWN
Hormone-receptor Positive Breast Cancer
GlaxoSmithKline
 2008-04 PHASE2
NCT00866528 COMPLETED
Lung Cancer, Non-Small Cell
GlaxoSmithKline
 2009-07-09 PHASE1
NCT01134055 COMPLETED
Macular Degeneration
GlaxoSmithKline
 2010-06-01 PHASE2
NCT01179269 WITHDRAWN
Non-small Cell Lung Cancer
Loyola University
 2010-03 PHASE2
NCT00945477 TERMINATED
Prostate Cancer
Illinois CancerCare, P.C.
 2009-07 PHASE2
NCT01227928 COMPLETED
Neoplasms, Ovarian
GlaxoSmithKline
 2010-09 PHASE2
NCT01253369 COMPLETED
Small Cell Lung Cancer; Lung Cancer; SCLC
Dana-Farber Cancer Institute
 2010-06 PHASE2
NCT00866697 COMPLETED
Ovarian Cancer
Novartis Pharmaceuticals
 2009-05-26 PHASE3
NCT01313663 TERMINATED
Lung Cancer, Small Cell
GlaxoSmithKline
 2011-02 PHASE2
NCT00722293 COMPLETED
Neoplasms, Breast
GlaxoSmithKline
 2008-07-08 PHASE1
NCT01035658 TERMINATED
Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Carcinoma
SCRI Development Innovations, LLC
 2010-01 PHASE1; PHASE2
NCT01147822 COMPLETED
Carcinoma, Renal Cell
Novartis Pharmaceuticals
 2010-05-19 PHASE2
NCT00720941 COMPLETED
Carcinoma, Renal Cell
Novartis Pharmaceuticals
 2008-08-14 PHASE3
NCT01362348 TERMINATED
Macular Degeneration
GlaxoSmithKline
 2011-07-07 PHASE2
NCT01394211 TERMINATED
Estrogen Receptor-positive Breast Cancer; Human Epidermal Growth Factor 2 Negative Carcinoma of Breast; Male Breast Cancer; Recurrent Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer
University of Arizona
 2011-07-13 PHASE2
NCT01099540 COMPLETED
Neuroendocrine Tumor
Samsung Medical Center
 2010-04 PHASE2
NCT01072890 COMPLETED
Solid Tumors
University of California, Davis
 2010-02 PHASE1
NCT01060514 TERMINATED
Metastatic Non Small Cell Lung Cancer; Metastatic Breast Cancer
Northwestern University
 2010-02 PHASE1
NCT01265940 COMPLETED
Advanced Urothelial Cancer of Bladder After Failure of Platinum-containing Therapy.
Prof. Dr. Thomas Otto
 2011-03 PHASE1; PHASE2
NCT01257750 COMPLETED
Corneal Neovascularization
Reza Dana, MD
 2010-11 PHASE1; PHASE2
NCT01498458 COMPLETED
Metastatic Breast Cancer
GBG Forschungs GmbH
 2010-10 PHASE1
NCT01031875 COMPLETED
Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
 2009-12 PHASE2
NCT00849472 COMPLETED
Neoplasms, Breast
GlaxoSmithKline
 2009-07 PHASE2
NCT01130623 WITHDRAWN
Sarcoma; Neuroblastoma; Wilms Tumor; Osteosarcoma; Brain Tumor
National Cancer Institute (NCI)
 2010-05-10 PHASE1
NCT01064310 COMPLETED
Carcinoma, Renal Cell
Novartis Pharmaceuticals
 2010-05-17 PHASE3
NCT01205230 COMPLETED
Cancer
GlaxoSmithKline
 2010-09 PHASE4
NCT00731211 COMPLETED
Renal Cell Carcinoma
SCRI Development Innovations, LLC
 2008-09 PHASE2
NCT00558103 COMPLETED
Neoplasms, Breast
GlaxoSmithKline
 2007-12 PHASE2
NCT01154062 COMPLETED
Macular Degeneration
GlaxoSmithKline
 2010-08-16 PHASE1
NCT00871403 COMPLETED
Lung Cancer, Non-Small Cell
GlaxoSmithKline
 2009-07 PHASE2
NCT00454571 COMPLETED
Recurrent Prostate Cancer
National Cancer Institute (NCI)
 2006-06 PHASE2
NCT01080248 TERMINATED
Pancreatic Cancer
Washington University School of Medicine
 2010-08 PHASE2
NCT00753688 COMPLETED
Sarcoma, Soft Tissue
GlaxoSmithKline
 2008-10 PHASE3
NCT00450879 TERMINATED
Male Breast Carcinoma; Recurrent Breast Carcinoma; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage IIIA Breast Cancer
National Cancer Institute (NCI)
 2007-01 PHASE1
NCT00861913 COMPLETED
Recurrent Melanoma; Stage IV Cutaneous Melanoma AJCC v6 and v7
National Cancer Institute (NCI)
 2009-04-03 PHASE2
NCT00516672 COMPLETED
Carcinoma, Renal Cell
GlaxoSmithKline
 2007-09-10 PHASE1
NCT00471536 COMPLETED
Distal Urethral Cancer; Proximal Urethral Cancer; Recurrent Bladder Cancer; Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter; Recurrent Urethral Cancer; Stage IV Bladder Cancer; Transitional Cell Carcinoma of the Bladder; Urethral Cancer Associated With Invasive Bladder Cancer
National Cancer Institute (NCI)
 2008-08 PHASE2
NCT00827372 COMPLETED
Lymphedema
Kathy Miller
 2009-01 PHASE2
NCT01072214 COMPLETED
Macular Degeneration
GlaxoSmithKline
 2010-03-09 PHASE1
NCT01051700 COMPLETED
Macular Degeneration
GlaxoSmithKline
 2010-01-12 PHASE1
NCT00540943 COMPLETED
Neoplasms, Colorectal
GlaxoSmithKline
 2007-07-13 PHASE1
NCT00454142 COMPLETED
Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx
National Cancer Institute (NCI)
 2007-08 PHASE2
NCT00678977 COMPLETED
Lung Cancer, Non-Small Cell
GlaxoSmithKline
 2008-04-03 PHASE1
NCT00861029 COMPLETED
Carcinoma, Renal Cell
GlaxoSmithKline
 2009-03-19 PHASE1
NCT00387764 COMPLETED
Carcinoma, Renal Cell
GlaxoSmithKline
 2006-09 PHASE3
NCT00350727 COMPLETED
Glioma
GlaxoSmithKline
 2006-12 PHASE2
NCT00733304 COMPLETED
Macular Degeneration
GlaxoSmithKline
 2008-06-25 PHASE2
NCT00619424 COMPLETED
Lung Cancer, Non-Small Cell
GlaxoSmithKline
 2007-11-15 PHASE1
NCT00387387 COMPLETED
Neoplasms, Colorectal
GlaxoSmithKline
 2006-10-20 PHASE1
NCT00388076 COMPLETED
Neoplasms, Breast
GlaxoSmithKline
 2006-04-28 PHASE1
NCT00509587 COMPLETED
Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer
National Cancer Institute (NCI)
 2007-06 PHASE2
NCT00363194 COMPLETED
Carcinoma, Renal Cell
GlaxoSmithKline
 2006-09-21 PHASE1
NCT00370513 COMPLETED
Carcinoma, Hepatocellular
GlaxoSmithKline
 2006-12-06 PHASE1
NCT00549328 TERMINATED
Lung Cancer, Non-Small Cell
GlaxoSmithKline
 2008-02 PHASE2
NCT00459862 COMPLETED
Advanced Malignant Mesothelioma; Localized Malignant Mesothelioma; Recurrent Malignant Mesothelioma
National Cancer Institute (NCI)
 2007-03 PHASE2
NCT00612456 COMPLETED
Macular Degeneration
GlaxoSmithKline
 2008-03-05 PHASE2
NCT00459381 COMPLETED
Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor
National Cancer Institute (NCI)
 2007-05 PHASE2
NCT00347919 COMPLETED
Neoplasms, Breast
GlaxoSmithKline
 2006-07 PHASE2
NCT00478725 COMPLETED
Carcinoma, Renal Cell
GlaxoSmithKline
 2007-07-18 PHASE1
NCT00430781 COMPLETED
Neoplasms, Uterine Cervix; Metastatic Cervical Cancer
GlaxoSmithKline
 2006-11 PHASE2
NCT00659555 COMPLETED
Macular Degeneration
GlaxoSmithKline
 2008-04-04 PHASE1
NCT00334282 COMPLETED
Carcinoma, Renal Cell
GlaxoSmithKline
 2006-04 PHASE3
NCT00367679 COMPLETED
Non-Small Cell Lung Cancer; Lung Cancer, Non-Small Cell
GlaxoSmithKline
 2006-11 PHASE2
NCT00561795 COMPLETED
Primary Peritoneal Carcinoma; Tumor; Epithelial Ovarian Cancer; Uterine Disease; Cervix Diseases; Neoplasms, Ovarian; Cancer
GlaxoSmithKline
 2007-09 PHASE2
NCT00401583 COMPLETED
Carcinoma, Renal Cell
GlaxoSmithKline
 2006-07-28 PHASE1
NCT00358384 COMPLETED
Psoriasis
GlaxoSmithKline
 2005-09-26 PHASE1
NCT00463320 COMPLETED
Macular Degeneration; Age-related Macular Degeneration
GlaxoSmithKline
 2007-03 PHASE1
NCT00060151 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
Case Comprehensive Cancer Center
 2002-12 PHASE1
NCT00256880 COMPLETED
Carcinoma, Renal Cell
GlaxoSmithKline
 2005-01 PHASE2
NCT00788580 WITHDRAWN
Unspecified Adult Solid Tumor, Protocol Specific
SWOG Cancer Research Network
 PHASE1

(data from https://clinicaltrials.gov, updated on 2026-08-03)

Check the Pazopanib HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Pazopanib HCl potently binds to receptor tyrosine kinases, primarily inhibiting VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, and c-Kit, which suppresses intracellular auto-phosphorylation and downstream pro-angiogenic signaling cascades. This biochemical blockade impairs endothelial cell proliferation and induces autophagic type II cell death, thereby halting tumor vascularization and disease progression in clinical conditions such as soft-tissue sarcoma and renal cell carcinoma.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.