CAS No. 900185-02-6
| IUPAC Name | 2-[[4-amino-3-(3-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one | |
|---|---|---|
| CAS Number | 900185-02-6 | |
| Molecular Formula |
C28H23N7O2 |
|
| Molecular Weight (MW) | 489.53 | |
| SMILES | CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C5=NC=NC(=C5C(=N4)C6=CC(=CC=C6)O)N | |
| InChIKey | WFSLJOPRIJSOJR-UHFFFAOYSA-N |
PIK-294 is a potent, isoform-selective inhibitor of PI3Kδ (IC50 =, displaying high selectivity over PI3Kα (1000-fold), PI3Kβ (49-fold), and PI3Kγ (16-fold). By selectively inhibiting p110δ kinase activity, PIK-294 suppresses downstream AKT/mTOR signaling pathways. This selective inhibition disrupts leukocyte proliferation and immune cell signaling, serving as a key research tool for dissecting isoform-specific functions within the PI3K signaling network. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(200.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.