CAS No. 1191951-57-1
Batch:
Purity:99.72
Chemical Structure
Check the
PHT-427
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide | |
|---|---|---|
| CAS Number | 1191951-57-1 | |
| Molecular Formula |
C20H31N3O2S2 |
|
| Molecular Weight (MW) | 409.61 | |
| SMILES | CCCCCCCCCCCCC1=CC=C(C=C1)S(=O)(=O)NC2=NN=CS2 | |
| InChIKey | BYWWNRBKPCPJMG-UHFFFAOYSA-N |
PHT-427 is a dual inhibitor of Akt and PDPK1 that binds to their pleckstrin homology domains. By suppressing PDPK1 and Akt activation, PHT-427 disrupts downstream AKT signaling pathways, leading to reduced cellular proliferation and inhibition of human tumor xenograft growth in vivo. Antitumor efficacy correlates closely with PDPK1 inhibition across sensitive cancer cell lines and xenograft models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(200.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 60 mg/mL |
| Water | Insoluble |
| DMSO |
82 mg/mL
(200.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 60 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.