CAS No. 718630-59-2

Batch: Purity:99.64
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PHA-793887 Chemical Structure
Chemical Structure
Check the PHA-793887 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[6,6-dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4-dihydropyrrolo[3,4-d]pyrazol-3-yl]-3-methylbutanamide
CAS Number 718630-59-2
Molecular Formula

C19H31N5O2
Molecular Weight (MW) 361.48
SMILES CC(C)CC(=O)NC1=NNC2=C1CN(C2(C)C)C(=O)C3CCN(CC3)C
InChIKey HUXYBQXJVXOMKX-UHFFFAOYSA-N

Biological Activity

PHA-793887 is a potent cyclin-dependent kinase inhibitor targeting CDK5, CDK2, and CDK7 (IC50 10 nM), with lower potency against CDK1, CDK4, and CDK9. Inhibition of these cyclin-dependent kinase complexes suppresses Retinoblastoma protein phosphorylation and downregulates S-phase cyclins such as cyclin A. Consequently, PHA-793887 inhibits tumor cell proliferation, induces cell-cycle arrest, and triggers apoptosis across multiple cancer cell models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 72 mg/mL (199.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 72 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Degrassi A, et al. Mol Cancer Ther. 2010;9(3):673-81.

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Note: Technical data last updated: Sep 1, 2026.