CAS No. 827318-97-8

Batch: Purity:99.55
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Danusertib (PHA-739358) Chemical Structure
Chemical Structure
Check the Danusertib (PHA-739358) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[5-[(2R)-2-methoxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-d]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
CAS Number 827318-97-8
Molecular Formula

C26H30N6O3
Molecular Weight (MW) 474.55
SMILES CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)C(C5=CC=CC=C5)OC
InChIKey XKFTZKGMDDZMJI-HSZRJFAPSA-N

Ordering Information

Biological Activity

Danusertib (PHA-739358) is a pyrrolo-pyrazole kinase inhibitor targeting Aurora A, Aurora B, and Aurora C, with additional activity against Abl, Ret, TrkA, and FGFR1. By disrupting Aurora kinase activity, it blocks cell cycle progression, inhibits cell proliferation, and induces apoptosis and autophagy in cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 95 mg/mL (200.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.