CAS No. 16837-52-8

Batch: Purity:99.52
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Oxymatrine Chemical Structure
Chemical Structure
Check the Oxymatrine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 16837-52-8
Molecular Formula

C15H24N2O2
Molecular Weight (MW) 264.36
SMILES C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-]

Ordering Information

Biological Activity

Oxymatrine is a natural quinolizidine alkaloid extracted from Sophora flavescens that exhibits potent anti-inflammatory, anti-fibrotic, and antitumor activities. It suppresses iNOS expression and downregulates pro-inflammatory cytokine production, including TNF-alpha and IL-6. Furthermore, oxymatrine inhibits the TGF-beta/Smad and NF-kB signaling pathways, thereby suppressing cellular proliferation, epithelial-mesenchymal transition, and fibrotic responses in various experimental models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 53 mg/mL (200.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 53 mg/mL
Ethanol 53 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.