CAS No. 55981-09-4
| IUPAC Name | [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate | |
|---|---|---|
| CAS Number | 55981-09-4 | |
| Molecular Formula |
C12H9N3O5S |
|
| Molecular Weight (MW) | 307.28 | |
| SMILES | CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-] | |
| InChIKey | YQNQNVDNTFHQSW-UHFFFAOYSA-N |
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and broad-spectrum antiprotozoal agent that targets pyruvate:ferredoxin oxidoreductase (PFOR) to disrupt electron transfer reactions. By interfering with anaerobic energy metabolism, it effectively impairs protozoal survival and growth. Furthermore, nitazoxanide modulates host autophagy and inhibits the mTORC1 signaling pathway, resulting in broad downstream suppression of viral replication across various host cells. [1][2]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(201.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 62 mg/mL |
| Water | Insoluble |
| DMSO |
61 mg/mL
(198.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
62 mg/mL
(201.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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