CAS No. 55981-09-4

Batch: Purity:99.97
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Nitazoxanide Chemical Structure
Chemical Structure
Check the Nitazoxanide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
CAS Number 55981-09-4
Molecular Formula

C12H9N3O5S
Molecular Weight (MW) 307.28
SMILES CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]
InChIKey YQNQNVDNTFHQSW-UHFFFAOYSA-N

Biological Activity

Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and broad-spectrum antiprotozoal agent that targets pyruvate:ferredoxin oxidoreductase (PFOR) to disrupt electron transfer reactions. By interfering with anaerobic energy metabolism, it effectively impairs protozoal survival and growth. Furthermore, nitazoxanide modulates host autophagy and inhibits the mTORC1 signaling pathway, resulting in broad downstream suppression of viral replication across various host cells. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 61 mg/mL (198.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Hoffman PS, et al. Antimicrob Agents Chemother. 2007;51(3):868-76.

[2] Rossignol JF. Antiviral Res. 2014;110:94-103.

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Note: Technical data last updated: Sep 1, 2026.