CAS No. 59-67-6
Batch:
Purity:99.95
Chemical Structure
Check the
Nicotinic Acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | pyridine-3-carboxylic acid | |
|---|---|---|
| CAS Number | 59-67-6 | |
| Molecular Formula |
C6H5NO2 |
|
| Molecular Weight (MW) | 123.11 | |
| SMILES | C1=CC(=CN=C1)C(=O)O | |
| InChIKey | PVNIIMVLHYAWGP-UHFFFAOYSA-N |
Biological Activity
Nicotinic acid is a water-soluble B-complex vitamin that acts as an agonist of hydroxycarboxylic acid receptor 2 (HCA2/GPR109A). It is converted into the essential coenzymes nicotinamide adenine dinucleotide (NAD) and NADP, which support cellular respiration and metabolic signaling pathways. Activation of HCA2 suppresses adipocyte lipolysis and modulates downstream lipid, amino acid, and carbohydrate metabolism to regulate cellular energy homeostasis. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(203.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 2 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.