CAS No. 105816-04-4
Batch:
Purity:99.88
Chemical Structure
Check the
Nateglinide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2R)-3-phenyl-2-[(4-propan-2-ylcyclohexanecarbonyl)amino]propanoic acid | |
|---|---|---|
| CAS Number | 105816-04-4 | |
| Molecular Formula |
C19H27NO3 |
|
| Molecular Weight (MW) | 317.42 | |
| SMILES | CC(C)C1CCC(CC1)C(=O)NC(CC2=CC=CC=C2)C(=O)O | |
| InChIKey | OELFLUMRDSZNSF-OFLPRAFFSA-N |
Biological Activity
Nateglinide is an insulin secretagogue that acts as an ATP-dependent potassium channel inhibitor to lower blood glucose levels. By closing ATP-dependent potassium channels in pancreatic beta cells, it depolarizes the plasma membrane and opens voltage-gated calcium channels. The resulting intracellular calcium influx stimulates the fusion of insulin-containing vesicles with the cell membrane, promoting rapid insulin secretion to regulate glucose homeostasis. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
63 mg/mL
(198.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 63 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.