CAS No. 7681-93-8

Batch: Purity:99.92
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Natamycin Chemical Structure
Chemical Structure
Check the Natamycin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
CAS Number 7681-93-8
Molecular Formula

C33H47NO13
Molecular Weight (MW) 665.73
SMILES CC1CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC3C(O3)C=CC(=O)O1)O)O)O)C(=O)O)OC4C(C(C(C(O4)C)O)N)O
InChIKey NCXMLFZGDNKEPB-FFPOYIOWSA-N

Ordering Information

Biological Activity

Natamycin (Pimaricin) is a macrolide polyene antifungal agent produced by Streptomyces natalensis that specifically binds to ergosterol in fungal cell membranes. This interaction disrupts ergosterol-dependent membrane transport proteins and inhibits endocytosis and membrane fusion without causing membrane permeabilization. Consequently, natamycin impairs fungal membrane function and halts cell growth, exhibiting potent antifungal activity against fungal pathogens such as Aspergillus and Fusarium species.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 10 mg/mL (15.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.