CAS No. 18916-17-1

Batch: Purity:99.77
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Naringin Dihydrochalcone Chemical Structure
Chemical Structure
Check the Naringin Dihydrochalcone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one
CAS Number 18916-17-1
Molecular Formula

C27H34O14
Molecular Weight (MW) 582.55
SMILES CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C(C(=C3)O)C(=O)CCC4=CC=C(C=C4)O)O)CO)O)O)O)O)O
InChIKey CWBZAESOUBENAP-QVNVHUMTSA-N

Ordering Information

Biological Activity

Naringin Dihydrochalcone is a synthetic dihydrochalcone sweetener and derivative of naringin that functions as an artificial sweetening agent and an inhibitor of cytochrome P450 (CYP) enzymes. By activating the sweet taste receptor heterodimer T1R2/T1R3, it stimulates sweet taste perception with significantly higher potency than sucrose. Additionally, modulation of CYP-mediated drug metabolism pathways and taste receptor activation affects downstream metabolic signaling and sensory perception. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (171.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.