CAS No. 550-99-2
Batch:
Purity:99.83
Chemical Structure
Check the
Naphazoline HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 550-99-2 | |
|---|---|---|
| Molecular Formula |
C14H14N2.HCl |
|
| Molecular Weight (MW) | 246.74 | |
| SMILES | C1CN=C(N1)CC2=CC=CC3=CC=CC=C32.Cl |
Naphazoline hydrochloride is an imidazoline-derived sympathomimetic amine and alpha-adrenergic receptor agonist. By directly stimulating alpha-adrenergic receptors on vascular smooth muscle, it induces potent vasoconstriction within the conjunctival vascular bed. This activation reduces local blood flow and mitigates vascular congestion through modulated adrenergic signaling pathways, making it a valuable tool for studying ocular vascular dynamics and adrenergic receptor mechanisms. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 49 mg/mL |
| Ethanol | 30 mg/mL |
| DMSO |
25 mg/mL
(101.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 49 mg/mL |
| Ethanol | 22 mg/mL |
| DMSO |
17 mg/mL
(68.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.