CAS No. 57149-08-3
Batch:
Purity:99.57
Chemical Structure
Check the
Naftopidil DiHCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 57149-08-3 | |
|---|---|---|
| Molecular Formula |
C24H28N2O3.2HCl |
|
| Molecular Weight (MW) | 465.41 | |
| SMILES | COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O.Cl.Cl |
Naftopidil DiHCl is a selective α1-adrenergic receptor and 5-HT1A receptor antagonist. It inhibits cell proliferation in androgen-sensitive LNCaP cells (IC50 = 22.2 μM) and androgen-insensitive PC-3 cells (IC50 = 33.2 μM) by inducing apoptosis. In vivo, oral administration of naftopidil significantly suppresses the growth of PC-3 xenograft tumors in nude mice, highlighting its potential utility in prostate cancer chemoprevention and therapy. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
41 mg/mL
(88.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.