CAS No. 103-16-2

Batch: Purity:99.85
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Monobenzone Chemical Structure
Chemical Structure
Check the Monobenzone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-phenylmethoxyphenol
CAS Number 103-16-2
Molecular Formula

C13H12O2
Molecular Weight (MW) 200.23
SMILES C1=CC=C(C=C1)COC2=CC=C(C=C2)O
InChIKey VYQNWZOUAUKGHI-UHFFFAOYSA-N

Biological Activity

Monobenzone is a topical depigmenting agent that acts as an inhibitor of tyrosinase. It inhibits melanin synthesis and decreases melanin excretion from melanocytes, triggering selective melanocyte toxicity and widespread skin depigmentation. Consequently, monobenzone is widely utilized to establish experimental animal models of vitiligo and to investigate cellular mechanisms of melanocyte clearance. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 40 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 40 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Encyclopedia of Cancer. 2011:856-856.

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Note: Technical data last updated: Sep 1, 2026.