CAS No. 22832-87-7
| IUPAC Name | 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid | |
|---|---|---|
| CAS Number | 22832-87-7 | |
| Molecular Formula |
C18H14Cl4N2O.HNO3 |
|
| Molecular Weight (MW) | 479.14 | |
| SMILES | C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-] | |
| InChIKey | MCCACAIVAXEFAL-UHFFFAOYSA-N |
Miconazole Nitrate is an imidazole antifungal agent that targets fungal cytochrome P450 14α-demethylase to inhibit ergosterol biosynthesis. This inhibition disrupts fungal cell membrane integrity, leading to increased membrane permeability and leakage of intracellular components. Additionally, miconazole induces reactive oxygen species (ROS) accumulation, which contributes to its fungicidal activity against fungal pathogens including Candida albicans.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(200.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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